登録情報 データベース : PDB / ID : 5e3a 構造の表示 ダウンロードとリンクタイトル Structure of human DPP3 in complex with opioid peptide leu-enkephalin 要素Dipeptidyl peptidase 3 Leu-enkephalin 詳細キーワード HYDROLASE / Peptide-complex / Zinc-hydrolase / opioid-peptide / peptidase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
synaptic vesicle lumen / neuronal dense core vesicle lumen / dipeptidyl-peptidase III / chromaffin granule lumen / opioid receptor binding / opioid peptide activity / synaptic signaling via neuropeptide / general adaptation syndrome, behavioral process / aggressive behavior / positive regulation of behavioral fear response ... synaptic vesicle lumen / neuronal dense core vesicle lumen / dipeptidyl-peptidase III / chromaffin granule lumen / opioid receptor binding / opioid peptide activity / synaptic signaling via neuropeptide / general adaptation syndrome, behavioral process / aggressive behavior / positive regulation of behavioral fear response / symmetric synapse / G protein-coupled opioid receptor signaling pathway / response to epinephrine / cell body fiber / sensory perception / cellular response to vitamin D / neuropeptide hormone activity / metalloexopeptidase activity / dipeptidyl-peptidase activity / startle response / transmission of nerve impulse / locomotory exploration behavior / response to immobilization stress / behavioral fear response / neuropeptide signaling pathway / glial cell proliferation / aminopeptidase activity / axon terminus / cellular response to cAMP / sensory perception of pain / cellular response to transforming growth factor beta stimulus / Peptide ligand-binding receptors / Post-translational protein phosphorylation / response to nicotine / protein catabolic process / response to toxic substance / cellular response to virus / response to calcium ion / osteoblast differentiation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / KEAP1-NFE2L2 pathway / response to estradiol / Neddylation / cellular response to oxidative stress / G alpha (i) signalling events / chemical synaptic transmission / perikaryon / response to ethanol / response to lipopolysaccharide / response to hypoxia / endoplasmic reticulum lumen / neuronal cell body / dendrite / signal transduction / proteolysis / zinc ion binding / extracellular exosome / extracellular region / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Fructose-1,6-Bisphosphatase; Chain A, domain 1 - #30 / Alpha-Beta Plaits - #2600 / Proenkephalin A / Dipeptidyl-peptidase 3 / Opioid neuropeptide precursor / Vertebrate endogenous opioids neuropeptide / Endogenous opioids neuropeptides precursors signature. / Peptidase family M49 / Peptidase family M49 / Fructose-1,6-Bisphosphatase; Chain A, domain 1 ... Fructose-1,6-Bisphosphatase; Chain A, domain 1 - #30 / Alpha-Beta Plaits - #2600 / Proenkephalin A / Dipeptidyl-peptidase 3 / Opioid neuropeptide precursor / Vertebrate endogenous opioids neuropeptide / Endogenous opioids neuropeptides precursors signature. / Peptidase family M49 / Peptidase family M49 / Fructose-1,6-Bisphosphatase; Chain A, domain 1 / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 : / Proenkephalin-A / Dipeptidyl peptidase 3 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.05 Å 詳細データ登録者 Kumar, P. / Reithofer, V. / Reisinger, M. / Pavkov-Keller, T. / Wallner, S. / Macheroux, P. / Gruber, K. 資金援助 オーストリア, 1件 詳細 詳細を隠す組織 認可番号 国 Austrian Science Fund W901 オーストリア
引用ジャーナル : Sci Rep / 年 : 2016タイトル : Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.著者 : Kumar, P. / Reithofer, V. / Reisinger, M. / Wallner, S. / Pavkov-Keller, T. / Macheroux, P. / Gruber, K. 履歴 登録 2015年10月2日 登録サイト : RCSB / 処理サイト : PDBE改定 1.0 2016年4月13日 Provider : repository / タイプ : Initial release改定 2.0 2017年9月6日 Group : Atomic model / Author supporting evidence / カテゴリ : atom_site / pdbx_audit_supportItem : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _pdbx_audit_support.funding_organization 改定 3.0 2024年1月10日 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Refinement description カテゴリ : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item : _atom_site.occupancy / _database_2.pdbx_DOI ... _atom_site.occupancy / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id