Entry Database : PDB / ID : 5dro Structure visualization Downloads & linksTitle Structure of the Aquifex aeolicus LpxC/LPC-011 Complex ComponentsUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Details Keywords hydrolase/hydrolase inhibitor / LpxC / Inhibitor / Lipid A / Gram-negative bacteria / hydrolase-hydrolase inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
UDP-3-O-acyl-N-acetylglucosamine deacetylase / UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity / UDP-3-O-acyl-N-acetylglucosamine deacetylase activity / lipid A biosynthetic process / metal ion binding Similarity search - Function lpxc deacetylase, domain 1 / lpxc deacetylase, domain 2 / lpxc deacetylase, domain 1 / UDP-3-O-acyl N-acetylglucosamine deacetylase / UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal / UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal / UDP-3-O-acyl N-acetylglycosamine deacetylase / Ribosomal Protein S5; domain 2 / Ribosomal protein S5 domain 2-type fold / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Aquifex aeolicus (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.01 Å DetailsAuthors Lee, C.-J. / Najeeb, J. / Zhou, P. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI055588 United States National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI094475 United States
CitationJournal : Nat Commun / Year : 2016Title : Drug design from the cryptic inhibitor envelope.Authors : Lee, C.J. / Liang, X. / Wu, Q. / Najeeb, J. / Zhao, J. / Gopalaswamy, R. / Titecat, M. / Sebbane, F. / Lemaitre, N. / Toone, E.J. / Zhou, P. History Deposition Sep 16, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 9, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2017 Group : Author supporting evidence / Derived calculations / Category : pdbx_audit_support / pdbx_struct_oper_listItem : _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.2 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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