Entry Database : PDB / ID : 5d3i Structure visualization Downloads & linksTitle Crystal structure of the SSL3-TLR2 complex ComponentsStaphylococcal Superantigen-Like protein 3 Toll-like receptor 2 DetailsKeywords IMMUNE SYSTEM / Superantigens / Superantigen-like proteins / SSL / SSL3 / Toll-like Receptor 2 / TLR2 / TLR6 / Immunology / Inflammation / Inhibition / Lipopeptide / phosphatidylcholine / PC / immune evasion / innate immunityFunction / homology Function and homology informationFunction Domain/homology Component
response to bacterial lipoprotein / diacyl lipopeptide binding / Beta defensins / triacyl lipopeptide binding / Toll-like receptor 2-Toll-like receptor 6 protein complex / detection of diacyl bacterial lipopeptide / positive regulation of neutrophil migration / cellular response to diacyl bacterial lipopeptide / Toll-like receptor 1-Toll-like receptor 2 protein complex / detection of triacyl bacterial lipopeptide ... response to bacterial lipoprotein / diacyl lipopeptide binding / Beta defensins / triacyl lipopeptide binding / Toll-like receptor 2-Toll-like receptor 6 protein complex / detection of diacyl bacterial lipopeptide / positive regulation of neutrophil migration / cellular response to diacyl bacterial lipopeptide / Toll-like receptor 1-Toll-like receptor 2 protein complex / detection of triacyl bacterial lipopeptide / cellular response to triacyl bacterial lipopeptide / cellular response to bacterial lipopeptide / Regulation of TLR by endogenous ligand / lipoteichoic acid binding / negative regulation of synapse assembly / response to molecule of fungal origin / cell surface pattern recognition receptor signaling pathway / regulation of dendritic cell cytokine production / response to peptidoglycan / positive regulation of xenophagy / positive regulation of interleukin-18 production / central nervous system myelin formation / xenophagy / leukotriene metabolic process / neutrophil migration / negative regulation of actin filament polymerization / response to fatty acid / lipopeptide binding / cellular response to peptidoglycan / negative regulation of interleukin-12 production / NAD+ nucleotidase, cyclic ADP-ribose generating / negative regulation of interleukin-17 production / microglia development / negative regulation of phagocytosis / positive regulation of macrophage cytokine production / positive regulation of leukocyte migration / positive regulation of intracellular signal transduction / MyD88-dependent toll-like receptor signaling pathway / pattern recognition receptor activity / toll-like receptor signaling pathway / positive regulation of oligodendrocyte differentiation / nitric oxide metabolic process / leukocyte migration / positive regulation of nitric-oxide synthase biosynthetic process / cellular response to lipoteichoic acid / positive regulation of interleukin-10 production / positive regulation of chemokine production / nitric oxide biosynthetic process / ERK1 and ERK2 cascade / positive regulation of interleukin-12 production / positive regulation of interferon-beta production / Neutrophil degranulation / learning / positive regulation of interleukin-1 beta production / positive regulation of cytokine production / cell projection / response to bacterium / microglial cell activation / defense response / positive regulation of inflammatory response / phagocytic vesicle membrane / transmembrane signaling receptor activity / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of nitric oxide biosynthetic process / signaling receptor activity / amyloid-beta binding / cell body / positive regulation of ERK1 and ERK2 cascade / defense response to Gram-positive bacterium / inflammatory response / membrane raft / negative regulation of cell population proliferation / external side of plasma membrane / innate immune response / protein-containing complex binding / Golgi apparatus / cell surface / positive regulation of transcription by RNA polymerase II / extracellular region / plasma membrane Similarity search - Function Staphylococcus aureus exotoxin / Staphylococcal superantigen-like OB-fold domain / Staphylococcal superantigen-like OB-fold domain / Toll-like receptor / Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site / Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. / Superantigen, staphylococcal/streptococcal toxin, bacterial / Ubiquitin-like (UB roll) - #120 / Superantigen toxin, C-terminal / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #110 ... Staphylococcus aureus exotoxin / Staphylococcal superantigen-like OB-fold domain / Staphylococcal superantigen-like OB-fold domain / Toll-like receptor / Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site / Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. / Superantigen, staphylococcal/streptococcal toxin, bacterial / Ubiquitin-like (UB roll) - #120 / Superantigen toxin, C-terminal / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #110 / Leucine Rich repeat / TIR domain / Enterotoxin / Leucine-rich repeats, bacterial type / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Ubiquitin-like (UB roll) / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Roll / Beta Barrel / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Staphylococcus aureus (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.2 Å DetailsAuthors Feitsma, L.J. / Huizinga, E.G. Funding support Netherlands, 3items Details Hide detailsOrganization Grant number Country Netherlands Organization for Scientific Research ECHO Grant 700.58.006 Netherlands Netherlands Organization for Health Research and Development ZonMw Grant 205200004 Netherlands Dutch Top Institute Pharma Project D1-101 Netherlands
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2015Title : Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3).Authors : Koymans, K.J. / Feitsma, L.J. / Brondijk, T.H. / Aerts, P.C. / Lukkien, E. / Lossl, P. / van Kessel, K.P. / de Haas, C.J. / van Strijp, J.A. / Huizinga, E.G. History Deposition Aug 6, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Aug 19, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 2, 2015 Group : Database referencesRevision 1.2 Sep 9, 2015 Group : Database referencesRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 May 1, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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