Entry Database : PDB / ID : 5cxw Structure visualization Downloads & linksTitle Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V ComponentsPenicillin-binding protein 1A Details Keywords PENICILLIN-BINDING PROTEIN/ANTIBIOTIC / b-lactam / PBP / Structural Genomics / PSI-Biology / Midwest Center for Structural Genomics / MCSG / Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors / MTBI / PENICILLIN-BINDING PROTEIN-ANTIBIOTIC complexFunction / homology Function and homology informationFunction Domain/homology Component
peptidoglycan glycosyltransferase / peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / serine-type D-Ala-D-Ala carboxypeptidase activity / penicillin binding / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / cellular response to hypoxia / outer membrane-bounded periplasmic space ... peptidoglycan glycosyltransferase / peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / serine-type D-Ala-D-Ala carboxypeptidase activity / penicillin binding / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / cellular response to hypoxia / outer membrane-bounded periplasmic space / response to antibiotic / proteolysis / plasma membrane Similarity search - Function Glycosyl transferase, family 51 / Penicillin binding protein transglycosylase domain / Transglycosylase / Penicillin-binding protein, transpeptidase / Penicillin binding protein transpeptidase domain / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like / Lysozyme-like domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Mycobacterium tuberculosis (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.75 Å DetailsAuthors Filippova, E.V. / Kiryukhina, O. / Kieser, K. / Endres, M. / Rubin, E. / Sacchettini, J. / Joachimiak, A. / Anderson, W.F. / Midwest Center for Structural Genomics (MCSG) / Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) CitationJournal : Febs J. / Year : 2016Title : Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.Authors : Filippova, E.V. / Kieser, K.J. / Luan, C.H. / Wawrzak, Z. / Kiryukhina, O. / Rubin, E.J. / Anderson, W.F. History Deposition Jul 29, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 4, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jul 6, 2016 Group : Database referencesRevision 1.2 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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