Entry Database : PDB / ID : 5ctd Structure visualization Downloads & linksTitle Crystal structure of the type IX collagen NC2 hetero-trimerization domain with a guest fragment a2a1a1 of type I collagen ComponentsCollagen alpha-1(I) chain,Collagen alpha-1(IX) chain Collagen alpha-1(I) chain,Collagen alpha-3(IX) chain Collagen alpha-2(I) chain,Collagen alpha-2(IX) chain DetailsKeywords STRUCTURAL PROTEIN / collagen / hetero-trimerization / chain stagger / chain register / triple helixFunction / homology Function and homology informationFunction Domain/homology Component
collagen type IX trimer / cellular response to fluoride / collagen type I trimer / tooth mineralization / protein heterotrimerization / cellular response to vitamin E / collagen type IV trimer / Anchoring fibril formation / Crosslinking of collagen fibrils / collagen biosynthetic process ... collagen type IX trimer / cellular response to fluoride / collagen type I trimer / tooth mineralization / protein heterotrimerization / cellular response to vitamin E / collagen type IV trimer / Anchoring fibril formation / Crosslinking of collagen fibrils / collagen biosynthetic process / Collagen chain trimerization / extracellular matrix assembly / Defective VWF binding to collagen type I / platelet-derived growth factor binding / bone trabecula formation / Enhanced cleavage of VWF variant by ADAMTS13 / Defective VWF cleavage by ADAMTS13 variant / Enhanced binding of GP1BA variant to VWF multimer:collagen / Defective binding of VWF variant to GPIb:IX:V / intramembranous ossification / embryonic skeletal system development / Extracellular matrix organization / cartilage development involved in endochondral bone morphogenesis / extracellular matrix structural constituent conferring tensile strength / Collagen biosynthesis and modifying enzymes / collagen metabolic process / skin morphogenesis / collagen-activated tyrosine kinase receptor signaling pathway / Signaling by PDGF / endochondral ossification / Platelet Adhesion to exposed collagen / NCAM1 interactions / cellular response to fibroblast growth factor stimulus / collagen fibril organization / negative regulation of cell-substrate adhesion / response to steroid hormone / face morphogenesis / odontogenesis / Scavenging by Class A Receptors / skin development / Assembly of collagen fibrils and other multimeric structures / MET activates PTK2 signaling / extracellular matrix structural constituent / Syndecan interactions / GP1b-IX-V activation signalling / blood vessel development / bone mineralization / SMAD binding / RUNX2 regulates osteoblast differentiation / Platelet Aggregation (Plug Formation) / Rho protein signal transduction / Collagen degradation / protein localization to nucleus / Non-integrin membrane-ECM interactions / ECM proteoglycans / response to hyperoxia / Integrin cell surface interactions / positive regulation of epithelial to mesenchymal transition / response to mechanical stimulus / cellular response to retinoic acid / cellular response to epidermal growth factor stimulus / GPVI-mediated activation cascade / cellular response to transforming growth factor beta stimulus / response to cAMP / visual perception / ossification / extracellular matrix organization / transforming growth factor beta receptor signaling pathway / secretory granule / skeletal system development / Cell surface interactions at the vascular wall / cellular response to glucose stimulus / animal organ morphogenesis / sensory perception of sound / cellular response to amino acid stimulus / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / response to insulin / response to hydrogen peroxide / regulation of blood pressure / cellular response to mechanical stimulus / osteoblast differentiation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / protein transport / positive regulation of canonical Wnt signaling pathway / response to estradiol / protein-macromolecule adaptor activity / cellular response to tumor necrosis factor / carbohydrate binding / Interleukin-4 and Interleukin-13 signaling / collagen-containing extracellular matrix / protease binding / positive regulation of cell migration / response to xenobiotic stimulus / endoplasmic reticulum lumen / positive regulation of DNA-templated transcription / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function : / Thrombospondin N-terminal -like domains. / Fibrillar collagen, C-terminal / Fibrillar collagen C-terminal domain / Fibrillar collagen C-terminal non-collagenous (NC1) domain profile. / Fibrillar collagens C-terminal domain / von Willebrand factor type C domain / VWFC domain signature. / VWFC domain profile. / von Willebrand factor (vWF) type C domain ... : / Thrombospondin N-terminal -like domains. / Fibrillar collagen, C-terminal / Fibrillar collagen C-terminal domain / Fibrillar collagen C-terminal non-collagenous (NC1) domain profile. / Fibrillar collagens C-terminal domain / von Willebrand factor type C domain / VWFC domain signature. / VWFC domain profile. / von Willebrand factor (vWF) type C domain / VWFC domain / Collagen triple helix repeat / Collagen triple helix repeat (20 copies) / Concanavalin A-like lectin/glucanase domain superfamily Similarity search - Domain/homology Collagen alpha-1(I) chain / Collagen alpha-2(I) chain / Collagen alpha-1(IX) chain / Collagen alpha-3(IX) chain / Collagen alpha-2(IX) chain Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 1.5991 Å DetailsAuthors Boudko, S.P. / Bachinger, H.P. Funding support United States, 1items Details Hide detailsOrganization Grant number Country Shriners Hospitals for Children United States
CitationJournal : Sci Rep / Year : 2016Title : Structural insight for chain selection and stagger control in collagen.Authors : Boudko, S.P. / Bachinger, H.P. History Deposition Jul 23, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 3, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jul 12, 2017 Group : Database references / Derived calculations / Category : citation / pdbx_struct_oper_listItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_struct_oper_list.symmetry_operation
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