CDC6 association with the ORC:origin complex / origin recognition complex / E2F-enabled inhibition of pre-replication complex formation / nuclear origin of replication recognition complex / inner kinetochore / Activation of the pre-replicative complex / Activation of ATR in response to replication stress / DNA replication origin binding / DNA replication initiation / heterochromatin ...CDC6 association with the ORC:origin complex / origin recognition complex / E2F-enabled inhibition of pre-replication complex formation / nuclear origin of replication recognition complex / inner kinetochore / Activation of the pre-replicative complex / Activation of ATR in response to replication stress / DNA replication origin binding / DNA replication initiation / heterochromatin / Assembly of the ORC complex at the origin of replication / Assembly of the pre-replicative complex / Orc1 removal from chromatin / chromosome, telomeric region / centrosome / negative regulation of transcription by RNA polymerase II / nucleoplasm / membrane / nucleus Similarity search - Function
Resolution: 2.01→47.66 Å / Cor.coef. Fo:Fc: 0.958 / Cor.coef. Fo:Fc free: 0.918 / WRfactor Rfree: 0.2429 / WRfactor Rwork: 0.1825 / FOM work R set: 0.8216 / SU B: 9.777 / SU ML: 0.132 / SU R Cruickshank DPI: 0.1792 / SU Rfree: 0.1801 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.179 / ESU R Free: 0.18 / Stereochemistry target values: MAXIMUM LIKELIHOOD Details: Data were reduced with HKL3000 for structure solution and early refinement. Molecular replacement was followed by simulated annealing refinement with PHENIX, subsequent phase improvement and ...Details: Data were reduced with HKL3000 for structure solution and early refinement. Molecular replacement was followed by simulated annealing refinement with PHENIX, subsequent phase improvement and automated model buidling with ARP/WARP. Diffraction data were reduced with XDS/AIMLESS for later refinement steps.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2573
837
9.7 %
RANDOM
Rwork
0.1896
7833
-
-
obs
0.196
8670
99.85 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
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