Entry Database : PDB / ID : 5c2j Structure visualization Downloads & linksTitle Complex structure of the GAP domain of MgcRacGAP and Cdc42 ComponentsCell division control protein 42 homolog Rac GTPase-activating protein 1 DetailsKeywords HYDROLASE ACTIVATOR/SIGNALING PROTEIN / GTPase activation / Complex / small G-protein / HYDROLASE ACTIVATOR-SIGNALING PROTEIN complexFunction / homology Function and homology informationFunction Domain/homology Component
DCC mediated attractive signaling / RHO GTPases activate KTN1 / centralspindlin complex / RHOV GTPase cycle / CD28 dependent Vav1 pathway / RHOQ GTPase cycle / RHOU GTPase cycle / RAC3 GTPase cycle / establishment or maintenance of apical/basal cell polarity / RAC2 GTPase cycle ... DCC mediated attractive signaling / RHO GTPases activate KTN1 / centralspindlin complex / RHOV GTPase cycle / CD28 dependent Vav1 pathway / RHOQ GTPase cycle / RHOU GTPase cycle / RAC3 GTPase cycle / establishment or maintenance of apical/basal cell polarity / RAC2 GTPase cycle / RHO GTPases activate PAKs / CDC42 GTPase cycle / actomyosin contractile ring assembly / G beta:gamma signalling through CDC42 / GPVI-mediated activation cascade / nucleus localization / EPHB-mediated forward signaling / EGFR downregulation / GBD domain binding / RHO GTPases Activate WASPs and WAVEs / Golgi transport complex / positive regulation of pinocytosis / RAC1 GTPase cycle / dendritic cell migration / endothelin receptor signaling pathway involved in heart process / mitotic spindle midzone assembly / cardiac neural crest cell migration involved in outflow tract morphogenesis / sulfate transmembrane transport / storage vacuole / RHO GTPases activate IQGAPs / apolipoprotein A-I receptor binding / positive regulation of epithelial cell proliferation involved in lung morphogenesis / RHO GTPases Activate Formins / neuron fate determination / regulation of attachment of spindle microtubules to kinetochore / RHOG GTPase cycle / positive regulation of pseudopodium assembly / MAPK6/MAPK4 signaling / Regulation of actin dynamics for phagocytic cup formation / cardiac conduction system development / host-mediated perturbation of viral process / Factors involved in megakaryocyte development and platelet production / heart process / regulation of filopodium assembly / leading edge membrane / neuropilin signaling pathway / Myogenesis / GTP-dependent protein binding / adherens junction organization / cell junction assembly / filopodium assembly / establishment of epithelial cell apical/basal polarity / dendritic spine morphogenesis / VEGFA-VEGFR2 Pathway / thioesterase binding / gamma-tubulin binding / RHOD GTPase cycle / embryonic heart tube development / Flemming body / Kinesins / regulation of postsynapse organization / regulation of small GTPase mediated signal transduction / positive regulation of filopodium assembly / endosomal transport / COPI-dependent Golgi-to-ER retrograde traffic / regulation of mitotic nuclear division / phagocytosis, engulfment / RHOB GTPase cycle / nuclear migration / heart contraction / positive regulation of cytokinesis / Rho GDP-dissociation inhibitor binding / spindle midzone / establishment or maintenance of cell polarity / RHOC GTPase cycle / cell leading edge / phosphatidylinositol-3,4,5-trisphosphate binding / mitotic cytokinesis / cleavage furrow / lamellipodium membrane / CDC42 GTPase cycle / regulation of embryonic development / RHOA GTPase cycle / neuroblast proliferation / RAC2 GTPase cycle / alpha-tubulin binding / RAC3 GTPase cycle / beta-tubulin binding / negative regulation of protein-containing complex assembly / Rho protein signal transduction / positive regulation of lamellipodium assembly / phagocytic vesicle / positive regulation of stress fiber assembly / monoatomic ion transport / RAC1 GTPase cycle / positive regulation of substrate adhesion-dependent cell spreading / acrosomal vesicle / MHC class II antigen presentation / GTPase activator activity / actin filament organization Similarity search - Function Phosphatidylinositol 3-kinase; Chain A / Rho GTPase activation protein / Cdc42 / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Small GTPase Rho / Small GTPase Rho domain profile. / Rho GTPase activation protein ... Phosphatidylinositol 3-kinase; Chain A / Rho GTPase activation protein / Cdc42 / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Small GTPase Rho / Small GTPase Rho domain profile. / Rho GTPase activation protein / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology ALUMINUM FLUORIDE / GUANOSINE-5'-DIPHOSPHATE / Cell division control protein 42 homolog / Rac GTPase-activating protein 1 Similarity search - ComponentBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Murayama, K. / Kato-Murayama, M. / Hosaka, T. / Kitamura, T. / Yokoyama, S. / Shirouzu, M. CitationJournal : J.Struct.Biol. / Year : 2024Title : Structural basis for the effects of Ser387 phosphorylation of MgcRacGAP on its GTPase-activating activities for CDC42 and RHOA.Authors : Murayama, K. / Kato-Murayama, M. / Hosaka, T. / Kitamura, T. / Yokoyama, S. / Shirouzu, M. History Deposition Jun 16, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Jun 22, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Feb 19, 2020 Group : Data collection / Derived calculations / Category : diffrn_source / pdbx_struct_oper_listItem : _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.2 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.3 Nov 20, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature / Item : _pdbx_entry_details.has_protein_modificationRevision 1.4 Dec 4, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
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