登録情報 データベース : PDB / ID : 5c1v 構造の表示 ダウンロードとリンクタイトル CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN 要素Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 詳細 キーワード HYDROLASE / 4-LAYER SANDWICH / SERINE/THREONINE PHOSPHATASE / CALCIUM BINDING機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of angiotensin-activated signaling pathway / regulation of cell proliferation involved in kidney morphogenesis / positive regulation of glomerulus development / negative regulation of calcium ion import across plasma membrane / negative regulation of signaling / positive regulation of saliva secretion / calcineurin complex / negative regulation of dendrite morphogenesis / positive regulation of connective tissue replacement / positive regulation of calcium ion import across plasma membrane ... negative regulation of angiotensin-activated signaling pathway / regulation of cell proliferation involved in kidney morphogenesis / positive regulation of glomerulus development / negative regulation of calcium ion import across plasma membrane / negative regulation of signaling / positive regulation of saliva secretion / calcineurin complex / negative regulation of dendrite morphogenesis / positive regulation of connective tissue replacement / positive regulation of calcium ion import across plasma membrane / slit diaphragm / positive regulation of cardiac muscle hypertrophy in response to stress / protein serine/threonine phosphatase complex / peptidyl-serine dephosphorylation / renal filtration / calcineurin-NFAT signaling cascade / positive regulation of calcineurin-NFAT signaling cascade / skeletal muscle tissue regeneration / transition between fast and slow fiber / positive regulation of osteoclast differentiation / cardiac muscle hypertrophy in response to stress / extrinsic component of plasma membrane / dendrite morphogenesis / dephosphorylation / CLEC7A (Dectin-1) induces NFAT activation / histone H2AXS139 phosphatase activity / RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity / RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity / MAP kinase serine/threonine phosphatase activity / calmodulin-dependent protein phosphatase activity / myosin phosphatase activity / protein serine/threonine phosphatase activity / protein-serine/threonine phosphatase / positive regulation of activated T cell proliferation / calcineurin-mediated signaling / positive regulation of endocytosis / Calcineurin activates NFAT / DARPP-32 events / epidermis development / multicellular organismal response to stress / positive regulation of osteoblast differentiation / postsynaptic modulation of chemical synaptic transmission / negative regulation of insulin secretion / keratinocyte differentiation / skeletal muscle fiber development / protein dephosphorylation / FCERI mediated Ca+2 mobilization / positive regulation of cell adhesion / response to amphetamine / T cell activation / excitatory postsynaptic potential / wound healing / modulation of chemical synaptic transmission / cellular response to glucose stimulus / sarcolemma / Schaffer collateral - CA1 synapse / Z disc / G1/S transition of mitotic cell cycle / response to calcium ion / protein import into nucleus / calcium ion transport / ATPase binding / Ca2+ pathway / dendritic spine / calmodulin binding / protein dimerization activity / positive regulation of cell migration / negative regulation of gene expression / calcium ion binding / positive regulation of gene expression / protein-containing complex binding / glutamatergic synapse / enzyme binding / positive regulation of transcription by RNA polymerase II / mitochondrion / nucleoplasm / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 PP2B, metallophosphatase domain / PP2B / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like ... PP2B, metallophosphatase domain / PP2B / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Metallo-dependent phosphatases / Purple Acid Phosphatase; chain A, domain 2 / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / 4-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 : / PHOSPHATE ION / Protein phosphatase 3 catalytic subunit alpha 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.35 Å 詳細データ登録者 Guasch, A. / Fita, I. / Perez-Luque, R. / Aparicio, D. / Aranguren-Ibanez, A. / Perez-Riba, M. 資金援助 スペイン, 4件 詳細 詳細を隠す組織 認可番号 国 Ministerio Ciencia Innovacion BFU2012-36827 スペイン Generalitat de Catalunya 2014SGR927 スペイン Ministerio Ciencia Innovacion SAF2009-08216 スペイン Generalitat de Catalunya 2009SGR1490 スペイン
引用ジャーナル : Plos One / 年 : 2015タイトル : Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.著者 : Guasch, A. / Aranguren-Ibanez, A. / Perez-Luque, R. / Aparicio, D. / Martinez-Hyer, S. / Mulero, M.C. / Serrano-Candelas, E. / Perez-Riba, M. / Fita, I. 履歴 登録 2015年6月15日 登録サイト : RCSB / 処理サイト : PDBE改定 1.0 2016年2月3日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月10日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _diffrn_radiation_wavelength.wavelength / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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