Entry | Database: PDB / ID: 5ayt |
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Title | Crystal structure of transthyretin in complex with L6 |
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Components | Transthyretin |
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Keywords | TRANSPORT PROTEIN/INHIBITOR / Amyloidogenic protein / Inhibitor / Stabilizer / Drug discovery / TRANSPORT PROTEIN-INHIBITOR complex |
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Function / homology | Function and homology information
Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ...Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein bindingSimilarity search - Function Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ...Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 1.4 Å |
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Authors | Yokoyama, T. / Mizuguchi, M. / Kai, H. |
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Citation | Journal: J. Pharmacol. Sci. / Year: 2015 Title: Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione Authors: Yokoyama, T. / Takaki, S. / Chosa, K. / Sato, T. / Suico, M.A. / Teranishi, Y. / Shuto, T. / Mizuguchi, M. / Kai, H. |
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History | Deposition | Sep 3, 2015 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Jan 20, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 26, 2020 | Group: Data collection / Derived calculations Category: diffrn_source / pdbx_prerelease_seq ...diffrn_source / pdbx_prerelease_seq / pdbx_struct_oper_list / pdbx_struct_special_symmetry Item: _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.2 | Mar 20, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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