- PDB-5ajj: Crystal structure of variola virus virulence factor F1L in comple... -
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Basic information
Entry
Database: PDB / ID: 5ajj
Title
Crystal structure of variola virus virulence factor F1L in complex with human Bid BH3 domain
Components
BH3-INTERACTING DOMAIN DEATH AGONIST
HOMOLOG OF VACCINIA VIRUS CDS F1L PUTATIVE
Keywords
VIRAL PROTEIN / BCL-2 / APOPTOSIS / POXVIRUS / BID
Function / homology
Function and homology information
: / cysteine-type endopeptidase regulator activity involved in apoptotic process / mitochondrial outer membrane permeabilization / Activation, translocation and oligomerization of BAX / host cell mitochondrial outer membrane / Activation and oligomerization of BAK protein / Activation, myristolyation of BID and translocation to mitochondria / positive regulation of fibroblast apoptotic process / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ...: / cysteine-type endopeptidase regulator activity involved in apoptotic process / mitochondrial outer membrane permeabilization / Activation, translocation and oligomerization of BAX / host cell mitochondrial outer membrane / Activation and oligomerization of BAK protein / Activation, myristolyation of BID and translocation to mitochondria / positive regulation of fibroblast apoptotic process / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / protein targeting to mitochondrion / regulation of epithelial cell proliferation / establishment of protein localization to membrane / death receptor binding / positive regulation of extrinsic apoptotic signaling pathway / positive regulation of mitochondrial membrane potential / regulation of T cell proliferation / hepatocyte apoptotic process / regulation of G1/S transition of mitotic cell cycle / positive regulation of release of cytochrome c from mitochondria / apoptotic mitochondrial changes / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / extrinsic apoptotic signaling pathway via death domain receptors / Activation of BAD and translocation to mitochondria / signal transduction in response to DNA damage / supramolecular fiber organization / positive regulation of intrinsic apoptotic signaling pathway / mitochondrial ATP synthesis coupled electron transport / release of cytochrome c from mitochondria / positive regulation of protein-containing complex assembly / protein-containing complex assembly / neuron apoptotic process / mitochondrial outer membrane / positive regulation of apoptotic process / ubiquitin protein ligase binding / mitochondrion / membrane / cytosol Similarity search - Function
Orthopoxvirus protein F1 / Poxvirus F1/C10 / Apoptosis regulator M11L like / BH3-interacting domain death agonist / BH3 interacting domain (BID) / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Bcl-2-like superfamily Similarity search - Domain/homology
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