Entry | Database: PDB / ID: 5a5o |
---|
Title | Crystal structure of human ATAD2 bromodomain in complex with 3-methyl- 1,2-dihydroquinolin-2-one |
---|
Components | ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2 |
---|
Keywords | HYDROLASE / INHIBITOR / ATAD2 / BROMODOMAIN / EPIGENETICS |
---|
Function / homology | Function and homology information
nucleosome disassembly / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / transcription initiation-coupled chromatin remodeling / nucleosome assembly / histone binding / chromatin binding / positive regulation of DNA-templated transcription / ATP hydrolysis activity / extracellular exosome ...nucleosome disassembly / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / transcription initiation-coupled chromatin remodeling / nucleosome assembly / histone binding / chromatin binding / positive regulation of DNA-templated transcription / ATP hydrolysis activity / extracellular exosome / nucleoplasm / ATP binding / nucleusSimilarity search - Function ATPase family AAA domain-containing protein ATAD2-like / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain ...ATPase family AAA domain-containing protein ATAD2-like / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / Mainly AlphaSimilarity search - Domain/homology |
---|
Biological species | HOMO SAPIENS (human) |
---|
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.04 Å |
---|
Authors | Chung, C. / Bamborough, P. / Demont, E. |
---|
Citation | Journal: J.Med.Chem. / Year: 2015 Title: Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors. Authors: Demont, E.H. / Chung, C. / Furze, R.C. / Grandi, P. / Michon, A. / Wellaway, C. / Barrett, N. / Bridges, A.M. / Craggs, P.D. / Diallo, H. / Dixon, D.P. / Douault, C. / Emmons, A.J. / Jones, ...Authors: Demont, E.H. / Chung, C. / Furze, R.C. / Grandi, P. / Michon, A. / Wellaway, C. / Barrett, N. / Bridges, A.M. / Craggs, P.D. / Diallo, H. / Dixon, D.P. / Douault, C. / Emmons, A.J. / Jones, E.J. / Karamshi, B.V. / Locke, K. / Mitchell, D.J. / Mouzon, B.H. / Prinjha, R.K. / Roberts, A.D. / Sheppard, R.J. / Watson, R.J. / Bamborough, P. |
---|
History | Deposition | Jun 20, 2015 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Jul 22, 2015 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Aug 5, 2015 | Group: Database references |
---|
Revision 1.2 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|