Entry Database : PDB / ID : 5a5p Structure visualization Downloads & linksTitle Crystal structure of human ATAD2 bromodomain in complex with 8-2-(dimethylamino)ethylamino-3-methyl-1,2-dihydroquinolin-2-one ComponentsATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2 Details Keywords HYDROLASE / INHIBITOR / ATAD2 / BROMODOMAIN / EPIGENETICS / ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2Function / homology Function and homology informationFunction Domain/homology Component
nucleosome disassembly / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / transcription initiation-coupled chromatin remodeling / nucleosome assembly / histone binding / chromatin binding / positive regulation of DNA-templated transcription / ATP hydrolysis activity / extracellular exosome ... nucleosome disassembly / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / transcription initiation-coupled chromatin remodeling / nucleosome assembly / histone binding / chromatin binding / positive regulation of DNA-templated transcription / ATP hydrolysis activity / extracellular exosome / nucleoplasm / ATP binding / nucleus Similarity search - Function ATPase family AAA domain-containing protein ATAD2-like / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain ... ATPase family AAA domain-containing protein ATAD2-like / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.03 Å DetailsAuthors Chung, C. / Bamborough, P. / Demont, E. CitationJournal : J.Med.Chem. / Year : 2015Title : Fragment-Based Discovery of Low-Micromolar Atad2 Bromodomain Inhibitors.Authors: Demont, E.H. / Chung, C. / Furze, R.C. / Grandi, P. / Michon, A. / Wellaway, C. / Barrett, N. / Bridges, A.M. / Craggs, P.D. / Diallo, H. / Dixon, D.P. / Douault, C. / Emmons, A.J. / Jones, ... Authors : Demont, E.H. / Chung, C. / Furze, R.C. / Grandi, P. / Michon, A. / Wellaway, C. / Barrett, N. / Bridges, A.M. / Craggs, P.D. / Diallo, H. / Dixon, D.P. / Douault, C. / Emmons, A.J. / Jones, E.J. / Karamshi, B.V. / Locke, K. / Mitchell, D.J. / Mouzon, B.H. / Prinjha, R.K. / Roberts, A.D. / Sheppard, R.J. / Watson, R.J. / Bamborough, P. History Deposition Jun 20, 2015 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 22, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Aug 5, 2015 Group : Database referencesRevision 1.2 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less