登録情報 データベース : PDB / ID : 4zud 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Human Angiotensin Receptor in Complex with Inverse Agonist Olmesartan at 2.8A resolution. 要素Chimera protein of Soluble cytochrome b562 and Type-1 angiotensin II receptor 詳細 キーワード MEMBRANE PROTEIN / human Angiotensin Receptor AT1R / BRIL / G Protein-Coupled Receptor / GPCR / GPCR network / Lipidic Cubic Phase / LCP / structural genomics / olmesartan / angiotensin receptor blocker / anti-hypertensive drug / PSI-Biology / SIGNALING PROTEIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
angiotensin type I receptor activity / positive regulation of phospholipase A2 activity / angiotensin type II receptor activity / phospholipase C-activating angiotensin-activated signaling pathway / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / bradykinin receptor binding / renin-angiotensin regulation of aldosterone production / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of macrophage derived foam cell differentiation ... angiotensin type I receptor activity / positive regulation of phospholipase A2 activity / angiotensin type II receptor activity / phospholipase C-activating angiotensin-activated signaling pathway / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / bradykinin receptor binding / renin-angiotensin regulation of aldosterone production / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of macrophage derived foam cell differentiation / positive regulation of CoA-transferase activity / low-density lipoprotein particle remodeling / regulation of systemic arterial blood pressure by renin-angiotensin / Rho protein signal transduction / regulation of vasoconstriction / positive regulation of protein metabolic process / blood vessel diameter maintenance / Peptide ligand-binding receptors / cell chemotaxis / kidney development / angiotensin-activated signaling pathway / regulation of cell growth / electron transport chain / calcium-mediated signaling / positive regulation of inflammatory response / Cargo recognition for clathrin-mediated endocytosis / positive regulation of reactive oxygen species metabolic process / Clathrin-mediated endocytosis / regulation of inflammatory response / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of cell population proliferation / positive regulation of cytosolic calcium ion concentration / G alpha (q) signalling events / periplasmic space / electron transfer activity / inflammatory response / symbiont entry into host cell / iron ion binding / protein heterodimerization activity / G protein-coupled receptor signaling pathway / heme binding / membrane / plasma membrane 類似検索 - 分子機能 Angiotensin II receptor type 1 / Angiotensin II receptor family / : / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM ... Angiotensin II receptor type 1 / Angiotensin II receptor family / : / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) 類似検索 - ドメイン・相同性 Olmesartan / Soluble cytochrome b562 / Type-1 angiotensin II receptor 類似検索 - 構成要素生物種 Escherichia coli (大腸菌)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.8 Å 詳細データ登録者 Zhang, H. / Unal, H. / Desnoyer, R. / Han, G.W. / Patel, N. / Katritch, V. / Karnik, S.S. / Cherezov, V. / Stevens, R.C. / GPCR Network (GPCR) 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) U54 GM094618 米国
引用ジャーナル : J.Biol.Chem. / 年 : 2015タイトル : Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.著者 : Zhang, H. / Unal, H. / Desnoyer, R. / Han, G.W. / Patel, N. / Katritch, V. / Karnik, S.S. / Cherezov, V. / Stevens, R.C. 履歴 登録 2015年5月15日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年10月7日 Provider : repository / タイプ : Initial release改定 1.1 2015年10月14日 Group : Database references改定 1.2 2015年12月16日 Group : Database references改定 1.3 2017年9月20日 Group : Author supporting evidence / Database references / Derived calculationsカテゴリ : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2019年12月25日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.5 2023年9月27日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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