regulation of B cell cytokine production / proteoglycan catabolic process / monocyte proliferation / positive regulation of interleukin-17A production / regulation of B cell apoptotic process / eosinophil homeostasis / positive regulation of type III hypersensitivity / B cell affinity maturation / positive regulation of synoviocyte proliferation / histamine secretion by mast cell ...regulation of B cell cytokine production / proteoglycan catabolic process / monocyte proliferation / positive regulation of interleukin-17A production / regulation of B cell apoptotic process / eosinophil homeostasis / positive regulation of type III hypersensitivity / B cell affinity maturation / positive regulation of synoviocyte proliferation / histamine secretion by mast cell / neutrophil homeostasis / cellular response to molecule of fungal origin / positive regulation of type I hypersensitivity / cellular response to interleukin-7 / MyD88 deficiency (TLR2/4) / MyD88-dependent toll-like receptor signaling pathway / IRAK4 deficiency (TLR2/4) / positive regulation of immunoglobulin production / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / positive regulation of B cell differentiation / positive regulation of NLRP3 inflammasome complex assembly / phospholipase activator activity / negative regulation of interleukin-10 production / B cell activation / negative regulation of B cell proliferation / Fc-epsilon receptor signaling pathway / mesoderm development / phosphatidylinositol-3,4,5-trisphosphate binding / phospholipase binding / RHO GTPases Activate WASPs and WAVEs / positive regulation of B cell proliferation / positive regulation of phagocytosis / cell maturation / FCERI mediated Ca+2 mobilization / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / calcium-mediated signaling / apoptotic signaling pathway / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / Regulation of actin dynamics for phagocytic cup formation / G beta:gamma signalling through BTK / cellular response to reactive oxygen species / peptidyl-tyrosine phosphorylation / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / G alpha (12/13) signalling events / DAP12 signaling / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / ER-Phagosome pathway / cytoplasmic vesicle / G alpha (q) signalling events / protein tyrosine kinase activity / adaptive immune response / Potential therapeutics for SARS / response to lipopolysaccharide / intracellular signal transduction / membrane raft / protein phosphorylation / innate immune response / perinuclear region of cytoplasm / ATP binding / identical protein binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長
波長: 1.127 Å / 相対比: 1
反射
解像度: 1.95→50 Å / Num. obs: 21777 / % possible obs: 99.2 % / 冗長度: 5.1 % / Rmerge(I) obs: 0.148 / Χ2: 1.101 / Net I/av σ(I): 10.146 / Net I/σ(I): 5.7 / Num. measured all: 111763
反射 シェル
Diffraction-ID: 1 / Rejects: _
解像度 (Å)
冗長度 (%)
Rmerge(I) obs
Num. unique all
Χ2
% possible all
1.95-1.98
4.7
0.651
1082
0.953
99.6
1.98-2.02
5.3
0.445
1069
0.902
100
2.02-2.06
5.1
0.519
1078
1.015
100
2.06-2.1
4.7
0.395
1054
1.243
99.5
2.1-2.15
5.2
0.375
1082
1.108
99.9
2.15-2.2
5.4
0.316
1062
1.07
99.9
2.2-2.25
5
0.305
1099
1.277
99.2
2.25-2.31
5
0.295
1056
1.289
99.2
2.31-2.38
5.5
0.233
1100
1.084
100
2.38-2.46
5.5
0.215
1059
1.113
100
2.46-2.54
5.5
0.198
1106
1.173
99.7
2.54-2.65
5.4
0.182
1074
1.182
99.6
2.65-2.77
5.1
0.171
1090
1.263
99.5
2.77-2.91
5.5
0.14
1096
1.185
100
2.91-3.1
5.5
0.116
1091
1.067
100
3.1-3.33
5.5
0.105
1095
1.033
99.7
3.33-3.67
4.3
0.094
1082
1.194
96.8
3.67-4.2
4.2
0.091
1065
0.971
95.3
4.2-5.29
5.3
0.081
1141
1.003
99
5.29-50
5
0.109
1196
0.926
97.5
-
解析
ソフトウェア
名称
バージョン
分類
HKL-2000
データ削減
HKL-2000
データスケーリング
REFMAC
5.7.0025
精密化
PDB_EXTRACT
3.15
データ抽出
精密化
解像度: 2→30 Å / Cor.coef. Fo:Fc: 0.949 / Cor.coef. Fo:Fc free: 0.908 / SU B: 7.641 / SU ML: 0.115 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.199 / ESU R Free: 0.183 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
反射数
%反射
Selection details
Rfree
0.2408
1014
5.1 %
RANDOM
Rwork
0.1756
-
-
-
obs
0.1788
18910
98.53 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK