- PDB-4zdr: Crystal structure of 14-3-3[zeta]-LKB1 fusion protein -
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Basic information
Entry
Database: PDB / ID: 4zdr
Title
Crystal structure of 14-3-3[zeta]-LKB1 fusion protein
Components
14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11
Keywords
PROTEIN BINDING / chimeric protein / regulatory protein / tumor suppressor / serine/threonine-protein kinase
Function / homology
Function and homology information
positive regulation of vesicle transport along microtubule / intracellular protein-containing complex / Golgi localization / LRR domain binding / AMPK inhibits chREBP transcriptional activation activity / Golgi reassembly / synaptic target recognition / dendrite extension / negative regulation of epithelial cell proliferation involved in prostate gland development / respiratory system process ...positive regulation of vesicle transport along microtubule / intracellular protein-containing complex / Golgi localization / LRR domain binding / AMPK inhibits chREBP transcriptional activation activity / Golgi reassembly / synaptic target recognition / dendrite extension / negative regulation of epithelial cell proliferation involved in prostate gland development / respiratory system process / serine/threonine protein kinase complex / NOTCH4 Activation and Transmission of Signal to the Nucleus / regulation of synapse maturation / establishment of Golgi localization / tissue homeostasis / epithelial cell proliferation involved in prostate gland development / response to thyroid hormone / Energy dependent regulation of mTOR by LKB1-AMPK / tube formation / positive thymic T cell selection / Rap1 signalling / vasculature development / regulation of Wnt signaling pathway / negative regulation of protein localization to nucleus / anoikis / response to glucagon / negative regulation of cold-induced thermogenesis / KSRP (KHSRP) binds and destabilizes mRNA / FOXO-mediated transcription of cell death genes / positive regulation of axonogenesis / regulation of dendrite morphogenesis / establishment of cell polarity / G1 to G0 transition / GP1b-IX-V activation signalling / response to ionizing radiation / cellular response to UV-B / response to lipid / activation of protein kinase activity / positive regulation of transforming growth factor beta receptor signaling pathway / protein kinase activator activity / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / Regulation of localization of FOXO transcription factors / intrinsic apoptotic signaling pathway by p53 class mediator / protein localization to nucleus / Interleukin-3, Interleukin-5 and GM-CSF signaling / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / protein targeting / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / positive regulation of autophagy / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / positive regulation of gluconeogenesis / negative regulation of TORC1 signaling / protein sequestering activity / ERK1 and ERK2 cascade / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / protein dephosphorylation / axonogenesis / regulation of ERK1 and ERK2 cascade / regulation of signal transduction by p53 class mediator / response to activity / Translocation of SLC2A4 (GLUT4) to the plasma membrane / Deactivation of the beta-catenin transactivating complex / regulation of cell growth / TP53 Regulates Metabolic Genes / Negative regulation of NOTCH4 signaling / peptidyl-threonine phosphorylation / lung development / regulation of protein stability / negative regulation of canonical Wnt signaling pathway / negative regulation of cell growth / autophagy / Z disc / positive regulation of protein localization to nucleus / melanosome / p53 binding / glucose homeostasis / T cell receptor signaling pathway / spermatogenesis / angiogenesis / DNA-binding transcription factor binding / vesicle / Regulation of TP53 Activity through Phosphorylation / transmembrane transporter binding / protein autophosphorylation / blood microparticle / non-specific serine/threonine protein kinase / regulation of cell cycle / cadherin binding / negative regulation of cell population proliferation / protein domain specific binding / protein phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / glutamatergic synapse Similarity search - Function
Serine/Threonine kinase LKB1, catalytic domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily ...Serine/Threonine kinase LKB1, catalytic domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology
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