Entry Database : PDB / ID : 4ys9 Structure visualization Downloads & linksTitle Ataxin-3 Carboxy-Terminal Region - Crystal C1 (tetragonal) ComponentsMaltose-binding periplasmic protein, Ataxin-3 chimera Details Keywords TRANSCRIPTION / Ataxin-3 / Polyglutamine / Huntington's Disease / Triplet repeat disorder / ataxins / ataxiaFunction / homology Function and homology informationFunction Domain/homology Component
protein localization to cytosolic proteasome complex / regulation of cell-substrate adhesion / positive regulation of ERAD pathway / monoubiquitinated protein deubiquitination / intermediate filament cytoskeleton organization / protein K48-linked deubiquitination / nuclear inclusion body / positive regulation of ubiquitin-dependent protein catabolic process / protein K63-linked deubiquitination / cellular response to misfolded protein ... protein localization to cytosolic proteasome complex / regulation of cell-substrate adhesion / positive regulation of ERAD pathway / monoubiquitinated protein deubiquitination / intermediate filament cytoskeleton organization / protein K48-linked deubiquitination / nuclear inclusion body / positive regulation of ubiquitin-dependent protein catabolic process / protein K63-linked deubiquitination / cellular response to misfolded protein / K48-linked deubiquitinase activity / K63-linked deubiquitinase activity / protein quality control for misfolded or incompletely synthesized proteins / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / maltodextrin transmembrane transport / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / negative regulation of TORC1 signaling / cellular response to amino acid starvation / Josephin domain DUBs / mitochondrial membrane / nucleotide-excision repair / nuclear matrix / microtubule cytoskeleton organization / nervous system development / cellular response to heat / ATPase binding / outer membrane-bounded periplasmic space / actin cytoskeleton organization / ubiquitin-dependent protein catabolic process / chemical synaptic transmission / proteasome-mediated ubiquitin-dependent protein catabolic process / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / mitochondrial matrix / lysosomal membrane / ubiquitin protein ligase binding / synapse / nucleolus / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Unstructured region C-term to UIM in Ataxin3 / Machado-Joseph disease protein / Josephin domain / Josephin / Josephin domain profile. / Josephin / Ubiquitin interaction motif / Ubiquitin-interacting motif. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. ... Unstructured region C-term to UIM in Ataxin3 / Machado-Joseph disease protein / Josephin domain / Josephin / Josephin domain profile. / Josephin / Ubiquitin interaction motif / Ubiquitin-interacting motif. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein Similarity search - Domain/homologyBiological species Escherichia coli (E. coli)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Zhemkov, V.A. / Kim, M. Funding support United States, Russian Federation, 6items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) R01NS074376 United States National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) R01NS056224 United States Russian Ministry of Science 11.G34.31.0056 Russian Federation Russian Scientific Fund 14-25-00024 Russian Federation Russian Ministry of Education and Science 17.1360.2014/K Russian Federation National Ataxia Foundation Translational Award United States
CitationJournal : FEBS Open Bio / Year : 2016Title : The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.Authors : Zhemkov, V.A. / Kulminskaya, A.A. / Bezprozvanny, I.B. / Kim, M. History Deposition Mar 16, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 9, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Mar 16, 2016 Group : Database referencesRevision 1.2 Sep 6, 2017 Group : Author supporting evidence / Derived calculations / Category : pdbx_audit_support / pdbx_struct_oper_listItem : _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.3 Nov 22, 2017 Group : Refinement description / Category : software / Item : _software.classificationRevision 1.4 Apr 18, 2018 Group : Data collection / Database references / Category : citationItem : _citation.journal_abbrev / _citation.pdbx_database_id_PubMed / _citation.titleRevision 1.5 Dec 18, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Non-polymer description / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.type / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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