Entry Database : PDB / ID : 4y8w Structure visualization Downloads & linksTitle Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex ComponentsCytochrome P450 21-hydroxylase Details Keywords OXIDOREDUCTASE / steroid hydroxylation / monooxygenases / adrenal steroidogenesis / congenital adrenal hyperplasia / Addison's disease / kinetic isotope effectsFunction / homology Function and homology informationFunction Domain/homology Component
Defective CYP21A2 causes AH3 / steroid 21-monooxygenase / steroid 21-monooxygenase activity / mineralocorticoid biosynthetic process / Mineralocorticoid biosynthesis / glucocorticoid biosynthetic process / Glucocorticoid biosynthesis / sterol metabolic process / steroid biosynthetic process / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ... Defective CYP21A2 causes AH3 / steroid 21-monooxygenase / steroid 21-monooxygenase activity / mineralocorticoid biosynthetic process / Mineralocorticoid biosynthesis / glucocorticoid biosynthetic process / Glucocorticoid biosynthesis / sterol metabolic process / steroid biosynthetic process / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen / steroid metabolic process / steroid hydroxylase activity / Endogenous sterols / monooxygenase activity / steroid binding / iron ion binding / heme binding / endoplasmic reticulum membrane Similarity search - Function Cytochrome P450, E-class, group I / Cytochrome p450 / Cytochrome P450 / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.64 Å DetailsAuthors Pallan, P.S. / Lei, L. / Egli, M. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM103937 United States
CitationJournal : J.Biol.Chem. / Year : 2015Title : Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.Authors : Pallan, P.S. / Wang, C. / Lei, L. / Yoshimoto, F.K. / Auchus, R.J. / Waterman, M.R. / Guengerich, F.P. / Egli, M. History Deposition Feb 16, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 15, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Apr 22, 2015 Group : Database referencesRevision 1.2 Jun 3, 2015 Group : Database referencesRevision 1.3 Sep 20, 2017 Group : Advisory / Author supporting evidence ... Advisory / Author supporting evidence / Database references / Derived calculations / Source and taxonomy Category : citation / entity_src_gen ... citation / entity_src_gen / pdbx_audit_support / pdbx_struct_oper_list / pdbx_validate_symm_contact Item : _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ... _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation Revision 1.4 Dec 25, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_symmetry / _struct_conn_type.id
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