登録情報 データベース : PDB / ID : 4y0f 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Human TDP-43 RRM1 Domain in Complex with an Unmodified Single-stranded DNA 要素DNA (5'-D(*GP*TP*TP*GP*AP*GP*CP*GP*TP*T)-3')TAR DNA-binding protein 43 詳細キーワード DNA BINDING PROTEIN/DNA / RNA recognition motif 1 Complex / DNA BINDING PROTEIN-DNA complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
nuclear inner membrane organization / interchromatin granule / perichromatin fibrils / 3'-UTR-mediated mRNA destabilization / 3'-UTR-mediated mRNA stabilization / intracellular non-membrane-bounded organelle / negative regulation by host of viral transcription / pre-mRNA intronic binding / response to endoplasmic reticulum stress / RNA splicing ... nuclear inner membrane organization / interchromatin granule / perichromatin fibrils / 3'-UTR-mediated mRNA destabilization / 3'-UTR-mediated mRNA stabilization / intracellular non-membrane-bounded organelle / negative regulation by host of viral transcription / pre-mRNA intronic binding / response to endoplasmic reticulum stress / RNA splicing / negative regulation of protein phosphorylation / molecular condensate scaffold activity / mRNA 3'-UTR binding / regulation of protein stability / regulation of circadian rhythm / positive regulation of insulin secretion / mRNA processing / positive regulation of protein import into nucleus / cytoplasmic stress granule / rhythmic process / regulation of gene expression / double-stranded DNA binding / regulation of apoptotic process / amyloid fibril formation / regulation of cell cycle / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / lipid binding / mitochondrion / DNA binding / RNA binding / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 : / TAR DNA-binding protein 43, C-terminal / TAR DNA-binding protein 43, N-terminal / TAR DNA-binding protein 43, N-terminal domain / RRM (RNA recognition motif) domain / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily ... : / TAR DNA-binding protein 43, C-terminal / TAR DNA-binding protein 43, N-terminal / TAR DNA-binding protein 43, N-terminal domain / RRM (RNA recognition motif) domain / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.648 Å 詳細データ登録者 Chiang, C.H. / Kuo, P.H. / Doudeva, L.G. / Wang, Y.T. / Yuan, H.S. 資金援助 台湾, 2件 詳細 詳細を隠す組織 認可番号 国 Academia Sinica 台湾 National Science Council 台湾
引用ジャーナル : Sci Rep / 年 : 2016タイトル : Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation著者 : Chiang, C.H. / Grauffel, C. / Wu, L.S. / Kuo, P.H. / Doudeva, L.G. / Lim, C. / Shen, C.K. / Yuan, H.S. 履歴 登録 2015年2月6日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2016年2月10日 Provider : repository / タイプ : Initial release改定 1.1 2016年3月9日 Group : Database references改定 1.2 2017年10月4日 Group : Derived calculations / Experimental preparation / カテゴリ : exptl_crystal_grow / pdbx_struct_oper_listItem : _exptl_crystal_grow.pH / _exptl_crystal_grow.pdbx_details / _pdbx_struct_oper_list.symmetry_operation改定 1.3 2023年11月8日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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