Entry Database : PDB / ID : 4xr7 Structure visualization Downloads & linksTitle Structure of the Saccharomyces cerevisiae PAN2-PAN3 core complex ComponentsPAB-dependent poly(A)-specific ribonuclease subunit PAN2 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 DetailsKeywords HYDROLASE / RNA degradation / Deadenylation / PseudokinaseFunction / homology Function and homology informationFunction Domain/homology Component
PAN complex / Deadenylation of mRNA / poly(A)-specific ribonuclease / poly(A)-specific ribonuclease activity / nuclear-transcribed mRNA poly(A) tail shortening / poly(A) binding / postreplication repair / P-body / mRNA processing / nucleic acid binding ... PAN complex / Deadenylation of mRNA / poly(A)-specific ribonuclease / poly(A)-specific ribonuclease activity / nuclear-transcribed mRNA poly(A) tail shortening / poly(A) binding / postreplication repair / P-body / mRNA processing / nucleic acid binding / protein kinase activity / DNA repair / RNA binding / ATP binding / metal ion binding / cytoplasm Similarity search - Function Helix Hairpins - #3700 / : / PAN2-PAN3 deadenylation complex subunit PAN3 / Pan3 pseudokinase domain / Pan3 Pseudokinase domain / PAN2, UCH domain / PAN2-PAN3 deadenylation complex catalytic subunit PAN2 / : / Ubiquitin carboxyl-terminal hydrolase / PAN2 N-terminal ... Helix Hairpins - #3700 / : / PAN2-PAN3 deadenylation complex subunit PAN3 / Pan3 pseudokinase domain / Pan3 Pseudokinase domain / PAN2, UCH domain / PAN2-PAN3 deadenylation complex catalytic subunit PAN2 / : / Ubiquitin carboxyl-terminal hydrolase / PAN2 N-terminal / Exonuclease / Exonuclease, RNase T/DNA polymerase III / EXOIII / Zinc finger, CCCH-type / Zinc finger C3H1-type profile. / Ubiquitin specific protease domain / Ubiquitin specific protease (USP) domain profile. / Cysteine proteinases / Quinoprotein alcohol dehydrogenase-like superfamily / Cathepsin B; Chain A / Papain-like cysteine peptidase superfamily / Helix Hairpins / Ribonuclease H superfamily / Ribonuclease H-like superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / WD40/YVTN repeat-like-containing domain superfamily / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha-Beta Complex / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Saccharomyces cerevisiae (brewer's yeast)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 3.796 Å DetailsAuthors Schafer, I.B. / Rode, M. / Bonneau, F. / Schussler, S. / Conti, E. Funding support Germany, 6items Details Hide detailsOrganization Grant number Country European Research Council 294371 Germany German Research Foundation SFB646 Germany German Research Foundation SFB1035 Germany German Research Foundation GRK1721 Germany German Research Foundation FOR1680 Germany German Research Foundation CIPSM Germany
CitationJournal : Nat. Struct. Mol. Biol. / Year : 2014Title : The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.Authors : Schafer, I.B. / Rode, M. / Bonneau, F. / Schussler, S. / Conti, E. History Deposition Jan 20, 2015 Deposition site : RCSB / Processing site : PDBESupersession Jan 28, 2015 ID : 4Q8J Details : D_1000206167 is an updated version of 4Q8J that resolves some issues of the original deposited structure such as cis-peptides and other discrepancies between NCS related chains.Revision 1.0 Jan 28, 2015 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2024 Group : Author supporting evidence / Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_audit_support Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization
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