Entry Database : PDB / ID : 4xqr Structure visualization Downloads & linksTitle Crystal structure of unliganded human FPPS at 2.15 angstrom resolution ComponentsFarnesyl pyrophosphate synthase Details Keywords TRANSFERASEFunction / homology Function and homology informationFunction Domain/homology Component
geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / Cholesterol biosynthesis / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / RNA binding ... geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / Cholesterol biosynthesis / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / RNA binding / nucleoplasm / metal ion binding / cytoplasm / cytosol Similarity search - Function Farnesyl pyrophosphate synthase-like / Polyprenyl synthases signature 1. / Polyprenyl synthases signature 2. / Polyprenyl synthetase, conserved site / Polyprenyl synthetase / Polyprenyl synthetase / Farnesyl Diphosphate Synthase / Farnesyl Diphosphate Synthase / Isoprenoid synthase domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution : 2.15 Å DetailsAuthors Park, J. / Berghuis, A.M. Funding support Canada, 1items Details Hide detailsOrganization Grant number Country Fonds de recherche Nature et technologies Canada
CitationJournal : To Be Published Title : Crystal structure of unliganded human FPPS at 2.15 angstrom resolutionAuthors : Park, J. / Berghuis, A.M. History Deposition Jan 20, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 20, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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