Entry Database : PDB / ID : 5ja0 Structure visualization Downloads & linksTitle Crystal structure of human FPPS with allosterically bound FPP ComponentsFarnesyl pyrophosphate synthase Details Keywords TRANSFERASEFunction / homology Function and homology informationFunction Domain/homology Component
geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / Cholesterol biosynthesis / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / RNA binding ... geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / Cholesterol biosynthesis / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / RNA binding / nucleoplasm / metal ion binding / cytoplasm / cytosol Similarity search - Function Farnesyl pyrophosphate synthase-like / Polyprenyl synthases signature 1. / Polyprenyl synthases signature 2. / Polyprenyl synthetase, conserved site / Polyprenyl synthetase / Polyprenyl synthetase / Farnesyl Diphosphate Synthase / Farnesyl Diphosphate Synthase / Isoprenoid synthase domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution : 1.9 Å DetailsAuthors Park, J. / Zielinski, M. / Tsantrizos, Y.S. / Berghuis, A.M. CitationJournal : Nat Commun / Year : 2017Title : Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.Authors : Park, J. / Zielinski, M. / Magder, A. / Tsantrizos, Y.S. / Berghuis, A.M. History Deposition Apr 11, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 25, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Feb 1, 2017 Group : Database referencesRevision 1.2 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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