登録情報 データベース : PDB / ID : 4xkx 構造の表示 ダウンロードとリンクタイトル Crystal structure of BACE1 in complex with 2-aminooxazoline 3-azaxanthene inhibitor 28 要素Beta-secretase 1 詳細 キーワード Hydrolase/hydrolase inhibitor / aspartic protease / Hydrolase-hydrolase inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / hippocampal mossy fiber to CA3 synapse / multivesicular body / response to lead ion / trans-Golgi network / protein processing / recycling endosome / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / synaptic vesicle / late endosome / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / lysosome / early endosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 解像度 : 1.8 Å 詳細データ登録者 Whittington, D.A. / Long, A.M. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2015タイトル : Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious beta-secretase inhibitors for the potential treatment of Alzheimer's disease.著者: Chen, J.J. / Liu, Q. / Yuan, C. / Gore, V. / Lopez, P. / Ma, V. / Amegadzie, A. / Qian, W. / Judd, T.C. / Minatti, A.E. / Brown, J. / Cheng, Y. / Xue, M. / Zhong, W. / Dineen, T.A. / Epstein, ... 著者 : Chen, J.J. / Liu, Q. / Yuan, C. / Gore, V. / Lopez, P. / Ma, V. / Amegadzie, A. / Qian, W. / Judd, T.C. / Minatti, A.E. / Brown, J. / Cheng, Y. / Xue, M. / Zhong, W. / Dineen, T.A. / Epstein, O. / Human, J. / Kreiman, C. / Marx, I. / Weiss, M.M. / Hitchcock, S.A. / Powers, T.S. / Chen, K. / Wen, P.H. / Whittington, D.A. / Cheng, A.C. / Bartberger, M.D. / Hickman, D. / Werner, J.A. / Vargas, H.M. / Everds, N.E. / Vonderfecht, S.L. / Dunn, R.T. / Wood, S. / Fremeau, R.T. / White, R.D. / Patel, V.F. 履歴 登録 2015年1月12日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年2月4日 Provider : repository / タイプ : Initial release改定 1.1 2015年2月18日 Group : Database references改定 1.2 2017年11月22日 Group : Database references / Derived calculations ... Database references / Derived calculations / Refinement description / Source and taxonomy カテゴリ : citation / entity_src_gen ... citation / entity_src_gen / pdbx_struct_oper_list / software Item : _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ... _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_struct_oper_list.symmetry_operation / _software.classification 改定 1.3 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_special_symmetry Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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