登録情報 | データベース: PDB / ID: 4xjj |
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タイトル | Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201 |
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要素 | TGF-beta receptor type-2 |
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キーワード | Cytokine Receptor / type II Transforming Growth Factor Beta receptor / NDSB-201 / Transforming Growth Factor Beta / kinase / extracellular domain |
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機能・相同性 | 機能・相同性情報
positive regulation of tolerance induction to self antigen / positive regulation of B cell tolerance induction / inferior endocardial cushion morphogenesis / transforming growth factor beta receptor activity, type II / bronchus morphogenesis / mammary gland morphogenesis / lens fiber cell apoptotic process / growth plate cartilage chondrocyte growth / tricuspid valve morphogenesis / activin receptor activity ...positive regulation of tolerance induction to self antigen / positive regulation of B cell tolerance induction / inferior endocardial cushion morphogenesis / transforming growth factor beta receptor activity, type II / bronchus morphogenesis / mammary gland morphogenesis / lens fiber cell apoptotic process / growth plate cartilage chondrocyte growth / tricuspid valve morphogenesis / activin receptor activity / TGFBR2 MSI Frameshift Mutants in Cancer / miRNA transport / transforming growth factor beta ligand-receptor complex / membranous septum morphogenesis / type III transforming growth factor beta receptor binding / lung lobe morphogenesis / aorta morphogenesis / Langerhans cell differentiation / positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / TGFBR2 Kinase Domain Mutants in Cancer / transforming growth factor beta receptor activity / cardiac left ventricle morphogenesis / secondary palate development / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / TGFBR3 regulates TGF-beta signaling / positive regulation of T cell tolerance induction / endocardial cushion fusion / positive regulation of NK T cell differentiation / outflow tract septum morphogenesis / myeloid dendritic cell differentiation / TGFBR1 LBD Mutants in Cancer / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / activin binding / regulation of stem cell proliferation / type I transforming growth factor beta receptor binding / SMAD protein signal transduction / embryonic cranial skeleton morphogenesis / positive regulation of CD4-positive, alpha-beta T cell proliferation / regulation of stem cell differentiation / glycosaminoglycan binding / kinase activator activity / response to cholesterol / transforming growth factor beta binding / aortic valve morphogenesis / positive regulation of mesenchymal cell proliferation / lens development in camera-type eye / atrioventricular valve morphogenesis / embryonic hemopoiesis / artery morphogenesis / trachea formation / smoothened signaling pathway / activation of protein kinase activity / ventricular septum morphogenesis / branching involved in blood vessel morphogenesis / positive regulation of epithelial cell migration / roof of mouth development / blood vessel development / heart looping / SMAD binding / TGF-beta receptor signaling activates SMADs / outflow tract morphogenesis / positive regulation of SMAD protein signal transduction / epithelial to mesenchymal transition / vasculogenesis / positive regulation of epithelial to mesenchymal transition / gastrulation / Notch signaling pathway / transforming growth factor beta receptor signaling pathway / Downregulation of TGF-beta receptor signaling / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / brain development / caveola / cellular response to growth factor stimulus / positive regulation of angiogenesis / positive regulation of reactive oxygen species metabolic process / UCH proteinases / heart development / regulation of cell population proliferation / regulation of gene expression / in utero embryonic development / molecular adaptor activity / receptor complex / response to xenobiotic stimulus / membrane raft / external side of plasma membrane / positive regulation of cell population proliferation / apoptotic process / extracellular space / extracellular region / ATP binding / membrane / metal ion binding / plasma membrane / cytosol類似検索 - 分子機能 Transforming growth factor beta receptor 2 ectodomain / Transforming growth factor-beta receptor, type II / Transforming growth factor beta receptor 2 ectodomain / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Ribbon / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase ...Transforming growth factor beta receptor 2 ectodomain / Transforming growth factor-beta receptor, type II / Transforming growth factor beta receptor 2 ectodomain / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Ribbon / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.4 Å |
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データ登録者 | Wangkanont, K. / Forest, K.T. / Kiessling, L.L. |
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引用 | ジャーナル: to be published タイトル: Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201 著者: Wangkanont, K. / Forest, K.T. / Kiessling, L.L. |
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履歴 | 登録 | 2015年1月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年6月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月27日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Source and taxonomy / Structure summary カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / entity_src_gen / pdbx_initial_refinement_model / pdbx_struct_assembly / pdbx_struct_oper_list / struct_keywords Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_src_gen.pdbx_alt_source_flag / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation / _struct_keywords.text |
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