- PDB-4xe5: Crystal structure of the Na,K-ATPase from bovine -
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Basic information
Entry
Database: PDB / ID: 4xe5
Title
Crystal structure of the Na,K-ATPase from bovine
Components
(Sodium/potassium-transporting ATPase subunit ...) x 3
Keywords
HYDROLASE / alpha-helical transmembrane protein / ATPase / sodium ion transport / potassium ion transport / ATP binding / sodium binding / receptor for cardiotonic steroids / plasma membrane / membrane protein / multisubunit complex / beryllium trifluoride
Function / homology
Function and homology information
Ion transport by P-type ATPases / : / positive regulation of calcium:sodium antiporter activity / positive regulation of potassium ion transmembrane transporter activity / Na+/K+-exchanging ATPase / positive regulation of sodium ion export across plasma membrane / positive regulation of potassium ion import across plasma membrane / : / Ion homeostasis / regulation of sodium ion transmembrane transporter activity ...Ion transport by P-type ATPases / : / positive regulation of calcium:sodium antiporter activity / positive regulation of potassium ion transmembrane transporter activity / Na+/K+-exchanging ATPase / positive regulation of sodium ion export across plasma membrane / positive regulation of potassium ion import across plasma membrane / : / Ion homeostasis / regulation of sodium ion transmembrane transporter activity / membrane repolarization / P-type sodium:potassium-exchanging transporter activity / sodium ion binding / sodium:potassium-exchanging ATPase complex / sodium ion export across plasma membrane / intracellular potassium ion homeostasis / ion channel regulator activity / intracellular sodium ion homeostasis / regulation of cardiac muscle contraction by calcium ion signaling / relaxation of cardiac muscle / sodium ion transport / potassium ion import across plasma membrane / organelle membrane / potassium ion binding / ATPase activator activity / intercalated disc / lateral plasma membrane / sperm flagellum / sodium channel regulator activity / cardiac muscle contraction / regulation of sodium ion transport / ATP metabolic process / proton transmembrane transport / T-tubule / protein localization to plasma membrane / potassium ion transport / sarcolemma / intracellular calcium ion homeostasis / ATPase binding / regulation of gene expression / basolateral plasma membrane / membrane => GO:0016020 / protein stabilization / cell adhesion / membrane raft / apical plasma membrane / protein kinase binding / ATP hydrolysis activity / ATP binding / metal ion binding / plasma membrane Similarity search - Function
Mass: 112824.531 Da / Num. of mol.: 1 / Source method: isolated from a natural source Details: BFD374 is an aspartate 374 that is covalently modified with beryllium fluoride Source: (natural) Bos taurus (cattle) / Organ: Kidney / References: UniProt: Q08DA1, EC: 3.6.3.9
#2: Protein
Sodium/potassium-transportingATPasesubunitbeta
Mass: 35068.254 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Bos taurus (cattle) / Organ: Kidney / References: UniProt: G3MWR4
#3: Protein
Sodium/potassium-transportingATPasesubunitgamma / Na(+)/K(+) ATPase subunit gamma / FXYD domain-containing ion transport regulator 2 / Sodium pump gamma chain
Mass: 6552.585 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Bos taurus (cattle) / Organ: Kidney / References: UniProt: Q04645
Resolution: 3.901→29.74 Å / SU ML: 0.78 / Cross valid method: FREE R-VALUE / σ(F): 2 / Phase error: 36.79 / Stereochemistry target values: ML Details: data was anisotropically truncated using the Diffraction Anisotropy Server (http://services.mbi.ucla.edu/anisoscale/)
Rfactor
Num. reflection
% reflection
Rfree
0.3363
731
5.08 %
Rwork
0.3224
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-
obs
0.3231
14398
64.93 %
Solvent computation
Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
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