Entry Database : PDB / ID : 4xbr Structure visualization Downloads & linksTitle In cellulo Crystal Structure of PAK4 in complex with Inka ComponentsProtein FAM212A,Serine/threonine-protein kinase PAK 4 Details Keywords Peptide / Transferase / PAK4 / Inka / CrystallizationFunction / homology Function and homology informationFunction Domain/homology Component
dendritic spine development / cadherin binding involved in cell-cell adhesion / protein serine/threonine kinase inhibitor activity / Activation of RAC1 / RHOV GTPase cycle / RHOJ GTPase cycle / RHOQ GTPase cycle / regulation of MAPK cascade / CDC42 GTPase cycle / RHOH GTPase cycle ... dendritic spine development / cadherin binding involved in cell-cell adhesion / protein serine/threonine kinase inhibitor activity / Activation of RAC1 / RHOV GTPase cycle / RHOJ GTPase cycle / RHOQ GTPase cycle / regulation of MAPK cascade / CDC42 GTPase cycle / RHOH GTPase cycle / RHOU GTPase cycle / cellular response to organic cyclic compound / RHOG GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / negative regulation of endothelial cell apoptotic process / cytoskeleton organization / RAC1 GTPase cycle / regulation of cell growth / adherens junction / positive regulation of angiogenesis / cell migration / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / cell cycle / phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / apoptotic process / protein kinase binding / Golgi apparatus / signal transduction / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function FAM212 domain / PAK4-inhibitor inka / FAM212 family / p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Transferase(Phosphotransferase) domain 1 ... FAM212 domain / PAK4-inhibitor inka / FAM212 family / p21 activated kinase binding domain / CRIB domain superfamily / P21-Rho-binding domain / CRIB domain profile. / P21-Rho-binding domain / CRIB domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.94 Å DetailsAuthors Baskaran, Y. / Ang, K.C. / Anekal, P.V. / Chan, W.L. / Grimes, J.M. / Manser, E. / Robinson, R.C. Funding support Singapore, 1items Details Hide detailsOrganization Grant number Country Agency for Science, Technology and Research Singapore
CitationJournal : Nat Commun / Year : 2015Title : An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1Authors : Baskaran, Y. / Ang, K.C. / Anekal, P.V. / Chan, W.L. / Grimes, J.M. / Manser, E. / Robinson, R.C. History Deposition Dec 17, 2014 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Dec 2, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Dec 9, 2015 Group : Database referencesRevision 1.2 Oct 4, 2017 Group : Data collection / Derived calculationsCategory : diffrn_detector / diffrn_source / pdbx_struct_oper_listItem : _diffrn_detector.detector / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.3 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
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