登録情報 | データベース: PDB / ID: 4xbm |
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タイトル | X-ray crystal structure of Notch ligand Delta-like 1 |
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要素 | Delta-like protein 1 |
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キーワード | SIGNALING PROTEIN / ectodomain EGF-like repeat Ligand C2 domain |
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機能・相同性 | 機能・相同性情報
cerebellar molecular layer formation / regulation of skeletal muscle tissue growth / Notch signaling pathway involved in arterial endothelial cell fate commitment / skin epidermis development / proximal tubule development / negative regulation of epidermal cell differentiation / regulation of vascular endothelial growth factor signaling pathway / somite specification / lateral inhibition / loop of Henle development ...cerebellar molecular layer formation / regulation of skeletal muscle tissue growth / Notch signaling pathway involved in arterial endothelial cell fate commitment / skin epidermis development / proximal tubule development / negative regulation of epidermal cell differentiation / regulation of vascular endothelial growth factor signaling pathway / somite specification / lateral inhibition / loop of Henle development / retina morphogenesis in camera-type eye / skeletal muscle tissue growth / endothelial tip cell fate specification / MECP2 regulates transcription of neuronal ligands / nephron development / cerebellar Purkinje cell layer structural organization / negative regulation of cardiac muscle cell differentiation / marginal zone B cell differentiation / negative regulation of inner ear auditory receptor cell differentiation / regulation of somitogenesis / compartment pattern specification / positive regulation of skeletal muscle tissue growth / neuron fate specification / Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant / negative regulation of myeloid cell differentiation / negative regulation of glial cell apoptotic process / left/right axis specification / proximal/distal pattern formation / Tat protein binding / type B pancreatic cell development / neuronal stem cell population maintenance / astrocyte development / clathrin-dependent endocytosis / cell fate determination / negative regulation of myoblast differentiation / determination of left/right symmetry / regulation of growth / Notch binding / negative regulation of epithelial cell differentiation / organ growth / spinal cord development / negative regulation of interleukin-10 production / positive regulation of Notch signaling pathway / negative regulation of Notch signaling pathway / positive regulation of sprouting angiogenesis / heart looping / regulation of cell division / plasma membrane => GO:0005886 / positive regulation of endocytosis / inner ear development / negative regulation of cell differentiation / hemopoiesis / regulation of neurogenesis / negative regulation of neuron differentiation / regulation of cell adhesion / somitogenesis / energy homeostasis / Notch signaling pathway / Constitutive Signaling by NOTCH1 HD Domain Mutants / NOTCH2 Activation and Transmission of Signal to the Nucleus / Activated NOTCH1 Transmits Signal to the Nucleus / NOTCH3 Activation and Transmission of Signal to the Nucleus / adherens junction / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / regulation of blood pressure / retina development in camera-type eye / cytoplasmic vesicle / scaffold protein binding / cell differentiation / apical plasma membrane / membrane raft / negative regulation of cell population proliferation / calcium ion binding / positive regulation of cell population proliferation / positive regulation of transcription by RNA polymerase II / extracellular region / plasma membrane類似検索 - 分子機能 Laminin - #140 / Immunoglobulin-like - #3510 / Delta/Serrate/lag-2 (DSL) protein / Notch ligand, N-terminal domain / Delta serrate ligand / N terminus of Notch ligand C2-like domain / DSL domain profile. / delta serrate ligand / EGF-like, conserved site / Human growth factor-like EGF ...Laminin - #140 / Immunoglobulin-like - #3510 / Delta/Serrate/lag-2 (DSL) protein / Notch ligand, N-terminal domain / Delta serrate ligand / N terminus of Notch ligand C2-like domain / DSL domain profile. / delta serrate ligand / EGF-like, conserved site / Human growth factor-like EGF / Laminin / Laminin / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
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データ登録者 | Kershaw, N.J. / Burgess, A.W. / Church, N.L. / Luo, C.S. / Adam, T.E. |
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資金援助 | オーストラリア, 1件 組織 | 認可番号 | 国 |
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National Health and Medical Research Council (NHMRC, Australia) | 487922 | オーストラリア |
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引用 | ジャーナル: Biochem.J. / 年: 2015 タイトル: Notch ligand delta-like1: X-ray crystal structure and binding affinity. 著者: Kershaw, N.J. / Church, N.L. / Griffin, M.D. / Luo, C.S. / Adams, T.E. / Burgess, A.W. |
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履歴 | 登録 | 2014年12月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年3月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年5月20日 | Group: Database references |
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改定 1.2 | 2015年5月27日 | Group: Data collection / Structure summary |
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改定 1.3 | 2017年9月6日 | Group: Author supporting evidence / Data collection ...Author supporting evidence / Data collection / Database references / Derived calculations / Source and taxonomy / Structure summary カテゴリ: citation / diffrn_source ...citation / diffrn_source / entity / entity_src_gen / pdbx_audit_support / pdbx_struct_assembly / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _diffrn_source.pdbx_synchrotron_site ..._citation.journal_id_CSD / _diffrn_source.pdbx_synchrotron_site / _entity.pdbx_description / _entity.src_method / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.4 | 2020年1月8日 | Group: Author supporting evidence / Data collection / カテゴリ: chem_comp / pdbx_audit_support Item: _chem_comp.type / _pdbx_audit_support.funding_organization |
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改定 1.5 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.6 | 2023年9月27日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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