登録情報 | データベース: PDB / ID: 4x3e |
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タイトル | Crystal structure of EED in complex with a trimethylated Jarid2 peptide |
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要素 | - ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER
- Polycomb protein EED
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キーワード | TRANSCRIPTION / Gene regulation / histone binding / WD40 |
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機能・相同性 | 機能・相同性情報
ESC/E(Z) complex / spinal cord development / histone methyltransferase activity / Transcriptional Regulation by E2F6 / nucleosome binding / enzyme activator activity / transcription corepressor binding / PRC2 methylates histones and DNA / Regulation of PTEN gene transcription / Defective pyroptosis ...ESC/E(Z) complex / spinal cord development / histone methyltransferase activity / Transcriptional Regulation by E2F6 / nucleosome binding / enzyme activator activity / transcription corepressor binding / PRC2 methylates histones and DNA / Regulation of PTEN gene transcription / Defective pyroptosis / PKMTs methylate histone lysines / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / chromosome / Oxidative Stress Induced Senescence / negative regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / cytosol類似検索 - 分子機能 YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat ...YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Justin, N. / Gamblin, S.J. / Margueron, R. |
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引用 | ジャーナル: Mol.Cell / 年: 2015 タイトル: Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. 著者: Sanulli, S. / Justin, N. / Teissandier, A. / Ancelin, K. / Portoso, M. / Caron, M. / Michaud, A. / Lombard, B. / da Rocha, S.T. / Offer, J. / Loew, D. / Servant, N. / Wassef, M. / Burlina, F. ...著者: Sanulli, S. / Justin, N. / Teissandier, A. / Ancelin, K. / Portoso, M. / Caron, M. / Michaud, A. / Lombard, B. / da Rocha, S.T. / Offer, J. / Loew, D. / Servant, N. / Wassef, M. / Burlina, F. / Gamblin, S.J. / Heard, E. / Margueron, R. |
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履歴 | 登録 | 2014年11月28日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2015年1月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年2月11日 | Group: Database references |
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改定 1.2 | 2015年3月18日 | Group: Database references |
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改定 1.3 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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