Entry Database : PDB / ID : 5k0m Structure visualization Downloads & linksTitle Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED ComponentsPolycomb protein EED Details Keywords PROTEIN BINDING / WD40 PRC2Function / homology Function and homology informationFunction Domain/homology Component
ESC/E(Z) complex / spinal cord development / histone methyltransferase activity / Transcriptional Regulation by E2F6 / nucleosome binding / enzyme activator activity / transcription corepressor binding / PRC2 methylates histones and DNA / Regulation of PTEN gene transcription / Defective pyroptosis ... ESC/E(Z) complex / spinal cord development / histone methyltransferase activity / Transcriptional Regulation by E2F6 / nucleosome binding / enzyme activator activity / transcription corepressor binding / PRC2 methylates histones and DNA / Regulation of PTEN gene transcription / Defective pyroptosis / PKMTs methylate histone lysines / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / chromosome / Oxidative Stress Induced Senescence / negative regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / cytosol Similarity search - Function YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat ... YVTN repeat-like/Quinoprotein amine dehydrogenase / 7 Propeller / Methylamine Dehydrogenase; Chain H / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.83 Å DetailsAuthors Jakob, C.G. / Bigelow, L.J. / Zhu, H. / Sun, C. CitationJournal : Nat. Chem. Biol. / Year : 2017Title : The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.Authors: He, Y. / Selvaraju, S. / Curtin, M.L. / Jakob, C.G. / Zhu, H. / Comess, K.M. / Shaw, B. / The, J. / Lima-Fernandes, E. / Szewczyk, M.M. / Cheng, D. / Klinge, K.L. / Li, H.Q. / Pliushchev, M. ... Authors : He, Y. / Selvaraju, S. / Curtin, M.L. / Jakob, C.G. / Zhu, H. / Comess, K.M. / Shaw, B. / The, J. / Lima-Fernandes, E. / Szewczyk, M.M. / Cheng, D. / Klinge, K.L. / Li, H.Q. / Pliushchev, M. / Algire, M.A. / Maag, D. / Guo, J. / Dietrich, J. / Panchal, S.C. / Petros, A.M. / Sweis, R.F. / Torrent, M. / Bigelow, L.J. / Senisterra, G. / Li, F. / Kennedy, S. / Wu, Q. / Osterling, D.J. / Lindley, D.J. / Gao, W. / Galasinski, S. / Barsyte-Lovejoy, D. / Vedadi, M. / Buchanan, F.G. / Arrowsmith, C.H. / Chiang, G.G. / Sun, C. / Pappano, W.N. History Deposition May 17, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 25, 2017 Provider : repository / Type : Initial releaseRevision 1.1 May 16, 2018 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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