登録情報 | データベース: PDB / ID: 4wxq |
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タイトル | Crystal Structure of the Myocilin Olfactomedin Domain |
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要素 | Myocilin |
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キーワード | PROTEIN BINDING / beta propeller / 5 bladed propeller / olfactomedin |
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機能・相同性 | 機能・相同性情報
skeletal muscle hypertrophy / clustering of voltage-gated sodium channels / myosin light chain binding / non-canonical Wnt signaling pathway / myelination in peripheral nervous system / node of Ranvier / frizzled binding / negative regulation of stress fiber assembly / negative regulation of Rho protein signal transduction / positive regulation of mitochondrial depolarization ...skeletal muscle hypertrophy / clustering of voltage-gated sodium channels / myosin light chain binding / non-canonical Wnt signaling pathway / myelination in peripheral nervous system / node of Ranvier / frizzled binding / negative regulation of stress fiber assembly / negative regulation of Rho protein signal transduction / positive regulation of mitochondrial depolarization / negative regulation of cell-matrix adhesion / ERBB2-ERBB3 signaling pathway / positive regulation of focal adhesion assembly / regulation of MAPK cascade / fibronectin binding / rough endoplasmic reticulum / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of stress fiber assembly / positive regulation of JNK cascade / bone development / mitochondrial intermembrane space / receptor tyrosine kinase binding / cilium / osteoblast differentiation / neuron projection development / cytoplasmic vesicle / collagen-containing extracellular matrix / mitochondrial outer membrane / mitochondrial inner membrane / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of cell migration / Golgi apparatus / endoplasmic reticulum / signal transduction / extracellular space / extracellular exosome / metal ion binding類似検索 - 分子機能 Olfactomedin-like domain / Olfactomedin-like domain / Olfactomedin-like domain profile. / Olfactomedin-like domains類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.15 Å |
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データ登録者 | Orwig, S.D. / Turnage, K.C. / Donegan, R.K. / Lieberman, R.L. |
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引用 | ジャーナル: Hum.Mol.Genet. / 年: 2015 タイトル: Structural basis for misfolding in myocilin-associated glaucoma. 著者: Donegan, R.K. / Hill, S.E. / Freeman, D.M. / Nguyen, E. / Orwig, S.D. / Turnage, K.C. / Lieberman, R.L. |
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履歴 | 登録 | 2014年11月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年4月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月6日 | Group: Author supporting evidence / Derived calculations / Source and taxonomy カテゴリ: entity_src_gen / pdbx_audit_support / pdbx_struct_oper_list Item: _entity_src_gen.pdbx_alt_source_flag / _pdbx_struct_oper_list.symmetry_operation |
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