登録情報 データベース : PDB / ID : 4wtu 構造の表示 ダウンロードとリンクタイトル Crystal structure of BACE1 in complex with 2-aminooxazoline 3-aza-4-fluoro-xanthene inhibitor 22 要素Beta-secretase 1 詳細 キーワード Hydrolase/Hydrolase Inhibitor / aspartic protease / amyloid precursor protein / Alzheimer's disease / Hydrolase-Hydrolase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.85 Å 詳細データ登録者 Whittington, D.A. / Long, A.M. 引用ジャーナル : Acs Med.Chem.Lett. / 年 : 2015タイトル : An Orally Available BACE1 Inhibitor That Affords Robust CNS A beta Reduction without Cardiovascular Liabilities.著者: Cheng, Y. / Brown, J. / Judd, T.C. / Lopez, P. / Qian, W. / Powers, T.S. / Chen, J.J. / Bartberger, M.D. / Chen, K. / Dunn, R.T. / Epstein, O. / Fremeau, R.T. / Harried, S. / Hickman, D. / ... 著者 : Cheng, Y. / Brown, J. / Judd, T.C. / Lopez, P. / Qian, W. / Powers, T.S. / Chen, J.J. / Bartberger, M.D. / Chen, K. / Dunn, R.T. / Epstein, O. / Fremeau, R.T. / Harried, S. / Hickman, D. / Hitchcock, S.A. / Luo, Y. / Minatti, A.E. / Patel, V.F. / Vargas, H.M. / Wahl, R.C. / Weiss, M.M. / Wen, P.H. / White, R.D. / Whittington, D.A. / Zheng, X.M. / Wood, S. 履歴 登録 2014年10月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年3月4日 Provider : repository / タイプ : Initial release改定 1.1 2017年11月22日 Group : Derived calculations / Other ... Derived calculations / Other / Refinement description / Source and taxonomy カテゴリ : entity_src_gen / pdbx_database_status ... entity_src_gen / pdbx_database_status / pdbx_struct_oper_list / software Item : _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation改定 1.2 2023年9月27日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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