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-Structure paper
Title | An Orally Available BACE1 Inhibitor That Affords Robust CNS A beta Reduction without Cardiovascular Liabilities. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 6, Page 210-215, Year 2015 |
Publish date | Oct 30, 2014 (structure data deposition date) |
Authors | Cheng, Y. / Brown, J. / Judd, T.C. / Lopez, P. / Qian, W. / Powers, T.S. / Chen, J.J. / Bartberger, M.D. / Chen, K. / Dunn, R.T. ...Cheng, Y. / Brown, J. / Judd, T.C. / Lopez, P. / Qian, W. / Powers, T.S. / Chen, J.J. / Bartberger, M.D. / Chen, K. / Dunn, R.T. / Epstein, O. / Fremeau, R.T. / Harried, S. / Hickman, D. / Hitchcock, S.A. / Luo, Y. / Minatti, A.E. / Patel, V.F. / Vargas, H.M. / Wahl, R.C. / Weiss, M.M. / Wen, P.H. / White, R.D. / Whittington, D.A. / Zheng, X.M. / Wood, S. |
External links | Acs Med. Chem. Lett. / PubMed:25699151 |
Methods | X-ray diffraction |
Resolution | 1.85 Å |
Structure data | PDB-4wtu: |
Chemicals | ChemComp-IOD: ChemComp-GOL: ChemComp-3UT: ChemComp-HOH: |
Source |
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Keywords | Hydrolase/Hydrolase Inhibitor / aspartic protease / amyloid precursor protein / Alzheimer's disease / Hydrolase-Hydrolase Inhibitor complex |