- PDB-4wk8: FOXP3 forms a domain-swapped dimer to bridge DNA -
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Basic information
Entry
Database: PDB / ID: 4wk8
Title
FOXP3 forms a domain-swapped dimer to bridge DNA
Components
DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3')
DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3')
Forkhead box protein P3
Keywords
TRANSCRIPTION/DNA / FOXP3 / regulatory T cells / DNA bridging / transcription regulation / TRANSCRIPTION-DNA complex
Function / homology
Function and homology information
positive regulation of peripheral T cell tolerance induction / CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment / establishment of endothelial blood-brain barrier / response to rapamycin / negative regulation of interleukin-4 production / negative regulation of CREB transcription factor activity / negative regulation of T cell cytokine production / negative regulation of chronic inflammatory response / transforming growth factor beta1 production / regulatory T cell differentiation ...positive regulation of peripheral T cell tolerance induction / CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment / establishment of endothelial blood-brain barrier / response to rapamycin / negative regulation of interleukin-4 production / negative regulation of CREB transcription factor activity / negative regulation of T cell cytokine production / negative regulation of chronic inflammatory response / transforming growth factor beta1 production / regulatory T cell differentiation / negative regulation of interleukin-5 production / regulation of isotype switching to IgG isotypes / tolerance induction to self antigen / negative regulation of defense response to virus / T cell mediated immunity / negative regulation of T-helper 17 cell differentiation / positive regulation of transforming growth factor beta1 production / T cell anergy / positive regulation of T cell anergy / immature T cell proliferation in thymus / negative regulation of isotype switching to IgE isotypes / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / isotype switching to IgE isotypes / CD4-positive, alpha-beta T cell proliferation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / positive regulation of immature T cell proliferation in thymus / negative regulation of immune response / negative regulation of CD4-positive, alpha-beta T cell proliferation / positive regulation of regulatory T cell differentiation / negative regulation of interleukin-17 production / regulation of T cell anergy / negative regulation of cytokine production / myeloid cell homeostasis / negative regulation of NF-kappaB transcription factor activity / histone acetyltransferase binding / negative regulation of interleukin-2 production / negative regulation of interleukin-10 production / RUNX1 regulates transcription of genes involved in WNT signaling / NFAT protein binding / positive regulation of interleukin-4 production / T cell homeostasis / negative regulation of activated T cell proliferation / negative regulation of interleukin-6 production / B cell homeostasis / negative regulation of tumor necrosis factor production / negative regulation of type II interferon production / NF-kappaB binding / negative regulation of T cell proliferation / T cell activation / response to virus / negative regulation of DNA-binding transcription factor activity / DNA-binding transcription repressor activity, RNA polymerase II-specific / histone deacetylase binding / transcription corepressor activity / sequence-specific double-stranded DNA binding / T cell receptor signaling pathway / DNA-binding transcription activator activity, RNA polymerase II-specific / sequence-specific DNA binding / transcription by RNA polymerase II / response to lipopolysaccharide / DNA-binding transcription factor activity, RNA polymerase II-specific / inflammatory response / chromatin remodeling / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / nucleoplasm / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function
: / FOXP, coiled-coil domain / FOXP coiled-coil domain / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Zinc finger C2H2 type domain signature. ...: / FOXP, coiled-coil domain / FOXP coiled-coil domain / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
A: DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3') B: DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3') F: Forkhead box protein P3 G: Forkhead box protein P3
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