登録情報 データベース : PDB / ID : 4uzq 構造の表示 ダウンロードとリンクタイトル STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH O-PALMITOLEOYL SERINE - CRYSTAL FORM IX - 1.5A 要素PROTEIN NOTUM HOMOLOG PROTEIN WNT-7A 詳細キーワード HYDROLASE / ESTERASE / EXTRACELLULAR / ALPHA/BETA HYDROLASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
postsynapse assembly / positive regulation of excitatory synapse assembly / regulation of axon diameter / positive regulation of protein localization to presynapse / skeletal muscle satellite cell activation / asymmetric protein localization involved in cell fate determination / excitatory synapse assembly / cerebellar granule cell differentiation / lens fiber cell development / synaptic vesicle recycling ... postsynapse assembly / positive regulation of excitatory synapse assembly / regulation of axon diameter / positive regulation of protein localization to presynapse / skeletal muscle satellite cell activation / asymmetric protein localization involved in cell fate determination / excitatory synapse assembly / cerebellar granule cell differentiation / lens fiber cell development / synaptic vesicle recycling / WNT ligand biogenesis and trafficking / oviduct development / central nervous system vasculogenesis / cell proliferation in forebrain / uterus morphogenesis / skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration / secondary palate development / embryonic axis specification / somatic stem cell division / presynapse assembly / sex differentiation / positive regulation of epithelial cell proliferation involved in wound healing / [Wnt protein] O-palmitoleoyl-L-serine hydrolase / protein depalmitoleylation / palmitoleyl hydrolase activity / stem cell development / establishment of blood-brain barrier / neurotransmitter secretion / phospholipase C activity / Release of Hh-Np from the secreting cell / dendritic spine morphogenesis / frizzled binding / regulation of bone mineralization / dorsal/ventral pattern formation / embryonic forelimb morphogenesis / Class B/2 (Secretin family receptors) / embryonic hindlimb morphogenesis / positive regulation of synapse assembly / wound healing, spreading of epidermal cells / Wnt signaling pathway, planar cell polarity pathway / regulation of postsynapse organization / regulation of synaptic vesicle exocytosis / embryonic digit morphogenesis / cartilage condensation / establishment of cell polarity / negative regulation of Wnt signaling pathway / somatic stem cell population maintenance / positive regulation of excitatory postsynaptic potential / regulation of presynapse assembly / canonical Wnt signaling pathway / cell fate commitment / chondrocyte differentiation / cellular response to transforming growth factor beta stimulus / positive regulation of protein metabolic process / positive regulation of endothelial cell migration / axonogenesis / extracellular matrix / cytokine activity / positive regulation of JNK cascade / Post-translational protein phosphorylation / Schaffer collateral - CA1 synapse / bone development / negative regulation of canonical Wnt signaling pathway / neuron differentiation / Wnt signaling pathway / negative regulation of neurogenesis / Golgi lumen / response to estrogen / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / endocytic vesicle membrane / presynapse / response to estradiol / angiogenesis / receptor ligand activity / endoplasmic reticulum lumen / signaling receptor binding / glutamatergic synapse / apoptotic process / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular exosome / extracellular region / plasma membrane 類似検索 - 分子機能 Wnt-7 protein / Wnt protein, conserved site / Wnt-1 family signature. / Wnt / Wnt, C-terminal domain / wnt family / found in Wnt-1 / Pectinacetylesterase/NOTUM / Pectinacetylesterase 類似検索 - ドメイン・相同性 PALMITOLEIC ACID / Protein Wnt-7a / Palmitoleoyl-protein carboxylesterase NOTUM 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / OTHER / 解像度 : 1.5 Å 詳細データ登録者 Zebisch, M. / Jones, E.Y. 引用ジャーナル : Nature / 年 : 2015タイトル : Notum Deacylates Wnt Proteins to Suppress Signalling Activity.著者 : Kakugawa, S. / Langton, P.F. / Zebisch, M. / Howell, S.A. / Chang, T. / Liu, Y. / Feizi, T. / Bineva, G. / O'Reilly, N. / Snijders, A.P. / Jones, E.Y. / Vincent, J. 履歴 登録 2014年9月7日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2015年2月25日 Provider : repository / タイプ : Initial release改定 1.1 2015年3月4日 Group : Structure summary改定 1.2 2015年3月18日 Group : Database references改定 1.3 2020年7月29日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Other / Structure summary カテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_nonpoly / pdbx_struct_conn_angle / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_database_status.status_code_sf / _pdbx_entity_nonpoly.name / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation
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