登録情報 | データベース: PDB / ID: 4uy4 |
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タイトル | 1.86 A structure of human Spindlin-4 protein in complex with histone H3K4me3 peptide |
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要素 | - HISTONE H3K4ME3
- SPINDLIN-4
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キーワード | PEPTIDE BINDING PROTEIN / SPINDLIN MEMBER 4 / SPIN4 / TUDOR DOMAIN / EPIGENETIC / CYSTICERCOSIS / MENINGOENCEPHALITIS |
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機能・相同性 | 機能・相同性情報
gamete generation / Chromatin modifying enzymes / epigenetic regulation of gene expression / methylated histone binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / Assembly of the ORC complex at the origin of replication / DNA methylation / Condensation of Prophase Chromosomes ...gamete generation / Chromatin modifying enzymes / epigenetic regulation of gene expression / methylated histone binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / Assembly of the ORC complex at the origin of replication / DNA methylation / Condensation of Prophase Chromosomes / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / HCMV Late Events / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NoRC negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / B-WICH complex positively regulates rRNA expression / HDMs demethylate histones / PKMTs methylate histone lysines / Meiotic recombination / RMTs methylate histone arginines / Pre-NOTCH Transcription and Translation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / nucleosome / nucleosome assembly / chromatin organization / RUNX1 regulates transcription of genes involved in differentiation of HSCs / Factors involved in megakaryocyte development and platelet production / gene expression / HATs acetylate histones / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / cadherin binding / protein heterodimerization activity / Amyloid fiber formation / regulation of DNA-templated transcription / protein-containing complex / DNA binding / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / cytosol類似検索 - 分子機能 Spindlin-4 / Spindlin/Ssty / Spindlin/spermiogenesis-specific protein / Spindlin/spermiogenesis-specific domain superfamily / Spin/Ssty Family / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 ...Spindlin-4 / Spindlin/Ssty / Spindlin/spermiogenesis-specific protein / Spindlin/spermiogenesis-specific domain superfamily / Spin/Ssty Family / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Histone H3 signature 1. / Histone H3 signature 2. / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-fold / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.862 Å |
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データ登録者 | Talon, R. / Gileadi, C. / Johansson, C. / Burgess-Brown, N. / Shrestha, L. / von Delft, F. / Krojer, T. / Fairhead, M. / Bountra, C. / Arrowsmith, C.H. ...Talon, R. / Gileadi, C. / Johansson, C. / Burgess-Brown, N. / Shrestha, L. / von Delft, F. / Krojer, T. / Fairhead, M. / Bountra, C. / Arrowsmith, C.H. / Edwards, A. / Oppermann, U. |
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引用 | ジャーナル: To be Published タイトル: 1.86 A Structure of Human Spindlin-4 Protein in Complex with Histone H3K4Me3 Peptide 著者: Talon, R. / Gileadi, C. / Johansson, C. / Burgess-Brown, N. / Shrestha, L. / Fairhead, M. / von Delft, F. / Krojer, T. / Bountra, C. / Arrowsmith, C.H. / Edwards, A. / Oppermann, U. |
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履歴 | 登録 | 2014年8月28日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2014年9月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年8月19日 | Group: Database references / Structure summary |
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改定 1.2 | 2018年1月24日 | Group: Database references / Structure summary / カテゴリ: audit_author / citation_author / Item: _audit_author.name / _citation_author.name |
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改定 1.3 | 2019年5月15日 | Group: Data collection / Derived calculations / Experimental preparation カテゴリ: exptl_crystal_grow / struct_conn Item: _exptl_crystal_grow.temp / _struct_conn.pdbx_leaving_atom_flag |
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改定 1.4 | 2024年1月10日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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