登録情報 データベース : PDB / ID : 4tpm 構造の表示 ダウンロードとリンクタイトル Crystal structure of 2-(3-alkoxy-1-azetidinyl) quinolines as PDE10A Inhibitors 要素cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 詳細 キーワード Hydrolase/Hydrolase Inhibitor / PDE10A / quinolines / Hydrolase-Hydrolase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity / 3',5'-cyclic-nucleotide phosphodiesterase / negative regulation of cGMP-mediated signaling / cGMP catabolic process / cGMP effects / cAMP catabolic process / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity / 3',5'-cyclic-nucleotide phosphodiesterase / negative regulation of cGMP-mediated signaling / cGMP catabolic process / cGMP effects / cAMP catabolic process / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP binding / cAMP-mediated signaling / G alpha (s) signalling events / metal ion binding / cytosol 類似検索 - 分子機能 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. ... Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / GAF domain / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Domain present in phytochromes and cGMP-specific phosphodiesterases. / GAF domain / GAF-like domain superfamily / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-35E / cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 解像度 : 2.77 Å 詳細データ登録者 Chmait, S. 引用ジャーナル : Bioorg.Med.Chem. / 年 : 2014タイトル : Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.著者: Rzasa, R.M. / Frohn, M.J. / Andrews, K.L. / Chmait, S. / Chen, N. / Clarine, J.G. / Davis, C. / Eastwood, H.A. / Horne, D.B. / Hu, E. / Jones, A.D. / Kaller, M.R. / Kunz, R.K. / Miller, S. / ... 著者 : Rzasa, R.M. / Frohn, M.J. / Andrews, K.L. / Chmait, S. / Chen, N. / Clarine, J.G. / Davis, C. / Eastwood, H.A. / Horne, D.B. / Hu, E. / Jones, A.D. / Kaller, M.R. / Kunz, R.K. / Miller, S. / Monenschein, H. / Nguyen, T. / Pickrell, A.J. / Porter, A. / Reichelt, A. / Zhao, X. / Treanor, J.J. / Allen, J.R. 履歴 登録 2014年6月8日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年12月17日 Provider : repository / タイプ : Initial release改定 1.1 2015年10月14日 Group : Data collection改定 1.2 2023年12月27日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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