登録情報 | データベース: PDB / ID: 4rlo |
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タイトル | Human p70s6k1 with ruthenium-based inhibitor EM5 |
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要素 | Ribosomal protein S6 kinase beta-1 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
long-chain fatty acid import into cell / response to electrical stimulus involved in regulation of muscle adaptation / skeletal muscle atrophy / positive regulation of skeletal muscle tissue growth / regulation of glucose import / ribosomal protein S6 kinase activity / response to L-leucine / cellular response to nutrient / response to glucagon / response to testosterone ...long-chain fatty acid import into cell / response to electrical stimulus involved in regulation of muscle adaptation / skeletal muscle atrophy / positive regulation of skeletal muscle tissue growth / regulation of glucose import / ribosomal protein S6 kinase activity / response to L-leucine / cellular response to nutrient / response to glucagon / response to testosterone / positive regulation of smooth muscle cell migration / mTORC1-mediated signalling / germ cell development / phosphatidylinositol-mediated signaling / skeletal muscle contraction / TOR signaling / behavioral fear response / positive regulation of translational initiation / response to tumor necrosis factor / long-term memory / response to glucose / response to mechanical stimulus / positive regulation of TORC1 signaling / protein serine/threonine/tyrosine kinase activity / negative regulation of insulin receptor signaling pathway / positive regulation of mitotic cell cycle / response to nutrient levels / cellular response to dexamethasone stimulus / protein phosphatase 2A binding / positive regulation of translation / PDZ domain binding / negative regulation of extrinsic apoptotic signaling pathway / peptide binding / positive regulation of smooth muscle cell proliferation / modulation of chemical synaptic transmission / response to toxic substance / cellular response to growth factor stimulus / cellular response to type II interferon / G1/S transition of mitotic cell cycle / cellular response to insulin stimulus / cell migration / postsynapse / peptidyl-serine phosphorylation / response to ethanol / mitochondrial outer membrane / response to lipopolysaccharide / non-specific serine/threonine protein kinase / protein kinase activity / response to xenobiotic stimulus / neuron projection / protein serine kinase activity / protein serine/threonine kinase activity / glutamatergic synapse / apoptotic process / negative regulation of apoptotic process / perinuclear region of cytoplasm / cell surface / signal transduction / mitochondrion / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Ribosomal protein S6 kinase / Protein kinase, C-terminal / Protein kinase C terminal domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Ribosomal protein S6 kinase / Protein kinase, C-terminal / Protein kinase C terminal domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-3T3 / STAUROSPORINE / Ribosomal protein S6 kinase beta-1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.527 Å |
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データ登録者 | Domsic, J.F. / Barber-Rotenberg, J. / Salami, J. / Qin, J. / Marmorstein, R. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2015 タイトル: Development of Organometallic S6K1 Inhibitors. 著者: Qin, J. / Rajaratnam, R. / Feng, L. / Salami, J. / Barber-Rotenberg, J.S. / Domsic, J. / Reyes-Uribe, P. / Liu, H. / Dang, W. / Berger, S.L. / Villanueva, J. / Meggers, E. / Marmorstein, R. |
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履歴 | 登録 | 2014年10月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年1月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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