登録情報 | データベース: PDB / ID: 4rav |
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タイトル | Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin |
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要素 | - Huntingtin
- Single-chain Fv, VL
- single-chain Fv, VH
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キーワード | IMMUNE SYSTEM/Apoptosis / immunoglobulin fold / immunity / 1-17 residues of huntingtin / IMMUNE SYSTEM-Apoptosis complex |
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機能・相同性 | 機能・相同性情報
positive regulation of CAMKK-AMPK signaling cascade / microtubule-based transport / vocal learning / positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity / positive regulation of mitophagy / regulation of CAMKK-AMPK signaling cascade / profilin binding / vesicle transport along microtubule / positive regulation of cilium assembly / retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ...positive regulation of CAMKK-AMPK signaling cascade / microtubule-based transport / vocal learning / positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity / positive regulation of mitophagy / regulation of CAMKK-AMPK signaling cascade / profilin binding / vesicle transport along microtubule / positive regulation of cilium assembly / retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum / positive regulation of aggrephagy / positive regulation of lipophagy / dynein intermediate chain binding / Golgi organization / beta-tubulin binding / establishment of mitotic spindle orientation / dynactin binding / phosphoprotein phosphatase activity / Regulation of MECP2 expression and activity / postsynaptic cytosol / presynaptic cytosol / inclusion body / heat shock protein binding / centriole / autophagosome / cytoplasmic vesicle membrane / negative regulation of extrinsic apoptotic signaling pathway / protein destabilization / kinase binding / p53 binding / late endosome / transmembrane transporter binding / early endosome / positive regulation of apoptotic process / axon / apoptotic process / dendrite / perinuclear region of cytoplasm / endoplasmic reticulum / Golgi apparatus / protein-containing complex / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Huntingtin / Huntingtin, middle-repeat / Huntingtin family / : / : / : / Huntingtin, N-terminal HEAT / Huntingtin, bridge / Huntingtin, N-terminal HEAT 1 / Huntingtin, C-terminal HEAT ...Huntingtin / Huntingtin, middle-repeat / Huntingtin family / : / : / : / Huntingtin, N-terminal HEAT / Huntingtin, bridge / Huntingtin, N-terminal HEAT 1 / Huntingtin, C-terminal HEAT / Armadillo-like helical / Armadillo-type fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | De Genst, E. / Chirgadze, D.Y. / Dobson, C.M. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2015 タイトル: Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression. 著者: De Genst, E. / Chirgadze, D.Y. / Klein, F.A. / Butler, D.C. / Matak-Vinkovic, D. / Trottier, Y. / Huston, J.S. / Messer, A. / Dobson, C.M. |
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履歴 | 登録 | 2014年9月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年7月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年11月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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