Entry | Database: PDB / ID: 4r7x |
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Title | Crystal structure of N-lobe of human ARRDC3(1-180) |
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Components | Arrestin domain-containing protein 3 |
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Keywords | PROTEIN BINDING / arrestin fold / GPCR downregulation / Beat 2 adrenergic receptor |
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Function / homology | Function and homology information
negative regulation of heat generation / beta-3 adrenergic receptor binding / negative regulation of locomotion involved in locomotory behavior / negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway / positive regulation of hippo signaling / heat generation / negative regulation of cold-induced thermogenesis / positive regulation of ubiquitin-protein transferase activity / fat pad development / skin development ...negative regulation of heat generation / beta-3 adrenergic receptor binding / negative regulation of locomotion involved in locomotory behavior / negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway / positive regulation of hippo signaling / heat generation / negative regulation of cold-induced thermogenesis / positive regulation of ubiquitin-protein transferase activity / fat pad development / skin development / protein transport / early endosome / lysosome / endosome / plasma membrane / cytoplasmSimilarity search - Function : / Immunoglobulin-like - #640 / Arrestin-like, N-terminal / Arrestin C-terminal-like domain / Arrestin (or S-antigen), N-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin-like, C-terminal / Immunoglobulin E-set / Immunoglobulin-like ...: / Immunoglobulin-like - #640 / Arrestin-like, N-terminal / Arrestin C-terminal-like domain / Arrestin (or S-antigen), N-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin-like, C-terminal / Immunoglobulin E-set / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.61 Å |
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Authors | Qi, S. / Hurley, J. |
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Citation | Journal: Protein Sci. / Year: 2014 Title: Insights into beta 2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Authors: Qi, S. / O'Hayre, M. / Gutkind, J.S. / Hurley, J.H. |
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History | Deposition | Aug 28, 2014 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 1, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 10, 2014 | Group: Database references |
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Revision 1.2 | Feb 28, 2024 | Group: Data collection / Database references / Derived calculations Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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