登録情報 | データベース: PDB / ID: 4r0z |
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タイトル | A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo |
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要素 | Protein humpback-2 |
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キーワード | CELL ADHESION / armadillo repeat |
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機能・相同性 | 機能・相同性情報
Degradation of beta-catenin by the destruction complex / Beta-catenin phosphorylation cascade / TCF dependent signaling in response to WNT / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / Formation of the cornified envelope / RHOH GTPase cycle / Transcriptional Regulation by VENTX / RUNX3 regulates WNT signaling / RHOA GTPase cycle / RHOB GTPase cycle ...Degradation of beta-catenin by the destruction complex / Beta-catenin phosphorylation cascade / TCF dependent signaling in response to WNT / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / Formation of the cornified envelope / RHOH GTPase cycle / Transcriptional Regulation by VENTX / RUNX3 regulates WNT signaling / RHOA GTPase cycle / RHOB GTPase cycle / RHOQ GTPase cycle / Deactivation of the beta-catenin transactivating complex / Formation of the beta-catenin:TCF transactivating complex / Apoptotic cleavage of cell adhesion proteins / VEGFR2 mediated vascular permeability / Ca2+ pathway / Neutrophil degranulation / embryonic body morphogenesis / cell migration involved in gastrulation / left/right axis specification / negative regulation of cell division / cell-cell adhesion mediated by cadherin / alpha-catenin binding / catenin complex / embryo development ending in birth or egg hatching / cortical actin cytoskeleton organization / molecular function inhibitor activity / establishment of mitotic spindle orientation / canonical Wnt signaling pathway / adherens junction / cell-cell adhesion / regulation of protein localization / cell migration / protein phosphatase binding / DNA-binding transcription factor binding / transcription coactivator activity / cadherin binding / protein domain specific binding / protein kinase binding / positive regulation of transcription by RNA polymerase II / nucleus / cytoplasm類似検索 - 分子機能 Beta-catenin / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / Armadillo-like helical / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha類似検索 - ドメイン・相同性 FORMIC ACID / Beta-catenin-like protein hmp-2類似検索 - 構成要素 |
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生物種 | ![](img/tx_invertebrata.gif) Caenorhabditis elegans (センチュウ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.005 Å |
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データ登録者 | Choi, H.-J. / Loveless, T. / Lynch, A. / Bang, I. / Hardin, J. / Weis, W.I. |
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引用 | ジャーナル: Dev.Cell / 年: 2015 タイトル: A Conserved Phosphorylation Switch Controls the Interaction between Cadherin and beta-Catenin In Vitro and In Vivo 著者: Choi, H.J. / Loveless, T. / Lynch, A.M. / Bang, I. / Hardin, J. / Weis, W.I. |
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履歴 | 登録 | 2014年8月3日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2015年4月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月8日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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