acetyltransferase activator activity / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone acetyltransferase complex / negative regulation of megakaryocyte differentiation / protein localization to CENP-A containing chromatin / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / Packaging Of Telomere Ends ...acetyltransferase activator activity / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone acetyltransferase complex / negative regulation of megakaryocyte differentiation / protein localization to CENP-A containing chromatin / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Deposition of new CENPA-containing nucleosomes at the centromere / Regulation of TP53 Activity through Acetylation / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere organization / RNA Polymerase I Promoter Opening / Assembly of the ORC complex at the origin of replication / SUMOylation of chromatin organization proteins / DNA methylation / Condensation of Prophase Chromosomes / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / HCMV Late Events / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Nonhomologous End-Joining (NHEJ) / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / NoRC negatively regulates rRNA expression / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / B-WICH complex positively regulates rRNA expression / G2/M DNA damage checkpoint / HDMs demethylate histones / DNA Damage/Telomere Stress Induced Senescence / PKMTs methylate histone lysines / Meiotic recombination / RMTs methylate histone arginines / Pre-NOTCH Transcription and Translation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / nucleosome / nucleosome assembly / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / chromatin organization / RUNX1 regulates transcription of genes involved in differentiation of HSCs / HATs acetylate histones / Processing of DNA double-strand break ends / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / chromosome, telomeric region / chromatin remodeling / protein heterodimerization activity / Amyloid fiber formation / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / protein-containing complex / DNA binding / RNA binding / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
Resolution: 1.94→34.43 Å / SU ML: 0.12 / σ(F): 1.37 / Phase error: 18.93 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Rfree
0.213
966
5.14 %
Rwork
0.175
-
-
obs
0.177
18780
99.7 %
all
-
18780
-
Solvent computation
Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement step
Cycle: LAST / Resolution: 1.94→34.43 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
995
0
0
143
1138
Refine LS restraints
Refine-ID
Type
Dev ideal
Number
X-RAY DIFFRACTION
f_bond_d
0.007
1014
X-RAY DIFFRACTION
f_angle_d
0.95
1361
X-RAY DIFFRACTION
f_dihedral_angle_d
12.875
392
X-RAY DIFFRACTION
f_chiral_restr
0.066
146
X-RAY DIFFRACTION
f_plane_restr
0.004
179
LS refinement shell
Resolution (Å)
Rfactor Rfree
Num. reflection Rfree
Rfactor Rwork
Num. reflection Rwork
Refine-ID
% reflection obs (%)
1.94-2.0435
0.2092
129
0.1709
2475
X-RAY DIFFRACTION
98
2.0435-2.1715
0.2178
124
0.1631
2494
X-RAY DIFFRACTION
100
2.1715-2.3392
0.1827
152
0.17
2496
X-RAY DIFFRACTION
100
2.3392-2.5745
0.1862
142
0.1724
2509
X-RAY DIFFRACTION
100
2.5745-2.9469
0.2323
136
0.1879
2554
X-RAY DIFFRACTION
100
2.9469-3.712
0.2174
128
0.1751
2584
X-RAY DIFFRACTION
100
3.712-34.4334
0.2214
155
0.1763
2702
X-RAY DIFFRACTION
100
Refinement TLS params.
Method: refined / Refine-ID: X-RAY DIFFRACTION
ID
L11 (°2)
L12 (°2)
L13 (°2)
L22 (°2)
L23 (°2)
L33 (°2)
S11 (Å °)
S12 (Å °)
S13 (Å °)
S21 (Å °)
S22 (Å °)
S23 (Å °)
S31 (Å °)
S32 (Å °)
S33 (Å °)
T11 (Å2)
T12 (Å2)
T13 (Å2)
T22 (Å2)
T23 (Å2)
T33 (Å2)
Origin x (Å)
Origin y (Å)
Origin z (Å)
1
5.4108
-1.244
0.0155
6.0042
0.5356
4.3278
-0.1516
-2.1388
-0.0482
1.3247
-0.03
-1.0712
0.6523
1.1199
-0.0107
0.2211
0.1663
-0.111
0.8282
0.176
0.2771
25.4797
84.2492
100.5969
2
5.8942
-1.547
-1.8234
3.8617
0.2883
2.0082
-0.1071
-0.7629
-0.2557
0.2265
0.0497
0.3069
-0.0514
0.0281
0.0526
0.1793
0.0099
0.0498
0.278
-0.0039
0.1789
4.0124
90.7519
99.5984
3
3.5762
-0.5241
-1.2526
1.9787
0.5419
2.5334
-0.2054
-0.6827
-0.7573
0.2374
0.192
0.2145
0.357
0.2452
-0.0042
0.2128
0.0298
0.0417
0.2858
0.0893
0.2476
14.5492
84.0801
96.1942
4
7.2357
-1.752
-1.4959
2.913
0.7923
2.363
0.3091
-0.3135
1.0751
0.0648
0.0151
-0.4337
-0.259
0.1843
-0.2866
0.1648
-0.0345
0.0235
0.1795
-0.0161
0.2065
17.7847
96.1331
92.6837
5
5.0365
4.4141
5.2693
4.4845
3.9937
6.1669
-0.087
-0.769
-1.6659
-0.3926
0.9089
-0.6738
1.1338
0.8484
-0.6526
0.5834
0.1729
-0.0941
0.8354
0.0089
1.0018
31.2406
77.4544
89.4081
6
6.8979
-2.2711
-0.0967
6.5191
-4.9717
4.3363
0.072
0.7045
0.5537
-0.501
-0.1674
-0.2522
0.3496
-0.677
0.1083
0.2076
0.0513
0.0461
0.3938
-0.0227
0.1733
-1.7363
98.0137
94.6083
Refinement TLS group
ID
Refine-ID
Refine TLS-ID
Selection details
1
X-RAY DIFFRACTION
1
chain 'A' and (resid4through22 )
2
X-RAY DIFFRACTION
2
chain 'A' and (resid23through49 )
3
X-RAY DIFFRACTION
3
chain 'A' and (resid50through82 )
4
X-RAY DIFFRACTION
4
chain 'A' and (resid83through112 )
5
X-RAY DIFFRACTION
5
chain 'A' and (resid113through117 )
6
X-RAY DIFFRACTION
6
chain 'B' and (resid6through13 )
+
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