Entry | Database: PDB / ID: 4qxe |
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Title | Crystal structure of LGR4 fused with hagfish VLR |
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Components | Leucine-rich repeat-containing G-protein coupled receptor 4, linker, Variable lymphocyte receptor B |
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Keywords | MEMBRANE PROTEIN / LRR repeats / Receptor / R-spondins / Glycosylation |
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Function / homology | Function and homology information
metanephric glomerulus development / metanephric nephron tubule morphogenesis / epithelial cell proliferation involved in renal tubule morphogenesis / protein-hormone receptor activity / intestinal stem cell homeostasis / negative regulation of toll-like receptor signaling pathway / positive regulation of branching involved in ureteric bud morphogenesis / male genitalia development / bone remodeling / G protein-coupled peptide receptor activity ...metanephric glomerulus development / metanephric nephron tubule morphogenesis / epithelial cell proliferation involved in renal tubule morphogenesis / protein-hormone receptor activity / intestinal stem cell homeostasis / negative regulation of toll-like receptor signaling pathway / positive regulation of branching involved in ureteric bud morphogenesis / male genitalia development / bone remodeling / G protein-coupled peptide receptor activity / digestive tract development / negative regulation of cold-induced thermogenesis / negative regulation of cytokine production / bone mineralization / hair follicle development / Regulation of FZD by ubiquitination / hormone-mediated signaling pathway / G protein-coupled receptor activity / circadian regulation of gene expression / adenylate cyclase-activating G protein-coupled receptor signaling pathway / Wnt signaling pathway / osteoblast differentiation / transmembrane signaling receptor activity / positive regulation of canonical Wnt signaling pathway / spermatogenesis / innate immune response / membrane / plasma membraneSimilarity search - Function Glycoprotein hormone receptor family / Variable lymphocyte receptor, C-terminal / Domain of unknown function (DUF3439) / Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Leucine Rich Repeat / Leucine-rich repeats, bacterial type / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor ...Glycoprotein hormone receptor family / Variable lymphocyte receptor, C-terminal / Domain of unknown function (DUF3439) / Leucine rich repeat N-terminal domain / Leucine-rich repeat N-terminal domain / Leucine rich repeat N-terminal domain / Leucine Rich Repeat / Leucine-rich repeats, bacterial type / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Leucine-rich repeat, SDS22-like subfamily / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human)
Eptatretus burgeri (inshore hagfish) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.2 Å |
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Authors | Xu, J.G. / Huang, C. / Zhu, Y. |
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Citation | Journal: TO BE PUBLISHED Title: Crystal structure of LGR4 fused with hagfish VLR Authors: Xu, J.G. / Huang, C. / Zhou, Y. / Zhu, Y. |
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History | Deposition | Jul 20, 2014 | Deposition site: RCSB / Processing site: PDBJ |
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Revision 1.0 | Oct 22, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 28, 2017 | Group: Source and taxonomy / Category: entity_src_gen |
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Revision 1.2 | Jul 29, 2020 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_ref_seq / struct_ref_seq_dif / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq_dif.details Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.3 | Nov 8, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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