- PDB-1zaw: Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form A -
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Basic information
Entry
Database: PDB / ID: 1zaw
Title
Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form A
Components
50S ribosomal protein L10
50S ribosomal protein L7/L12
Keywords
STRUCTURAL PROTEIN / ribosome structure and function / L10-L12 complex structure / L10E structure / L7/12 ribosomal stalk / thiostrepton loop of 23S rRNA / translation factor recruitment / GTPase stimulation / mechanism of translation / rapid kinetics
Function / homology
Function and homology information
large ribosomal subunit rRNA binding / cytosolic large ribosomal subunit / structural constituent of ribosome / translation / mRNA binding Similarity search - Function
Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #290 / Ribosomal protein L10, N-terminal RNA-binding domain / Ribosomal protein L7/L12, oligomerisation / Ribosomal protein L7/L12, oligomerisation domain superfamily / Ribosomal protein L7/L12 dimerisation domain / Ribosomal protein L7/L12 / Ribosomal protein L7/L12, C-terminal / Ribosomal protein L7/L12 C-terminal domain / Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like / Ribosomal protein L10, eubacterial, conserved site ...Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #290 / Ribosomal protein L10, N-terminal RNA-binding domain / Ribosomal protein L7/L12, oligomerisation / Ribosomal protein L7/L12, oligomerisation domain superfamily / Ribosomal protein L7/L12 dimerisation domain / Ribosomal protein L7/L12 / Ribosomal protein L7/L12, C-terminal / Ribosomal protein L7/L12 C-terminal domain / Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like / Ribosomal protein L10, eubacterial, conserved site / Ribosomal protein L10 signature. / Ribosomal protein L10 / : / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Ribosomal protein L10-like domain superfamily / Ribosomal protein L10 / Ribosomal protein L10P / Helix non-globular / Special / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
Journal: Cell / Year: 2005 Title: Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation. Authors: Mihaela Diaconu / Ute Kothe / Frank Schlünzen / Niels Fischer / Jörg M Harms / Alexander G Tonevitsky / Holger Stark / Marina V Rodnina / Markus C Wahl / Abstract: The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 ...The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain dimers, refine the structure of an archaeal L10E N-terminal domain on the 50S subunit, and identify these elements in cryo-electron-microscopic reconstructions of Escherichia coli ribosomes. The mobile C-terminal helix alpha8 of L10 carries three L7/12 dimers in T. maritima and two in E. coli, in concordance with the different length of helix alpha8 of L10 in these organisms. The stalk is organized into three elements (stalk base, L10 helix alpha8-L7/12 N-terminal-domain complex, and L7/12 C-terminal domains) linked by flexible connections. Highly mobile L7/12 C-terminal domains promote recruitment of translation factors to the ribosome and stimulate GTP hydrolysis by the ribosome bound factors through stabilization of their active GTPase conformation.
A: 50S ribosomal protein L10 U: 50S ribosomal protein L7/L12 V: 50S ribosomal protein L7/L12 W: 50S ribosomal protein L7/L12 X: 50S ribosomal protein L7/L12 Y: 50S ribosomal protein L7/L12 Z: 50S ribosomal protein L7/L12
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