positive regulation of intestinal epithelial cell development / Toll Like Receptor 9 (TLR9) Cascade / regulation of toll-like receptor 9 signaling pathway / cellular response to chloroquine / regulation of B cell activation / Trafficking and processing of endosomal TLR / PI3K Cascade / detection of molecule of bacterial origin / regulation of B cell differentiation / endolysosome ...positive regulation of intestinal epithelial cell development / Toll Like Receptor 9 (TLR9) Cascade / regulation of toll-like receptor 9 signaling pathway / cellular response to chloroquine / regulation of B cell activation / Trafficking and processing of endosomal TLR / PI3K Cascade / detection of molecule of bacterial origin / regulation of B cell differentiation / endolysosome / cellular response to metal ion / regulation of dendritic cell cytokine production / positive regulation of toll-like receptor 9 signaling pathway / maintenance of gastrointestinal epithelium / positive regulation of interleukin-18 production / positive regulation of B cell activation / unmethylated CpG binding / toll-like receptor 9 signaling pathway / siRNA binding / early phagosome / interleukin-1 receptor binding / positive regulation of granulocyte macrophage colony-stimulating factor production / MyD88-dependent toll-like receptor signaling pathway / pattern recognition receptor activity / positive regulation of immunoglobulin production / toll-like receptor signaling pathway / positive regulation of interleukin-10 production / canonical NF-kappaB signal transduction / positive regulation of interferon-alpha production / positive regulation of autophagy / positive regulation of chemokine production / positive regulation of B cell proliferation / positive regulation of interleukin-12 production / activation of innate immune response / positive regulation of interferon-beta production / phagocytic vesicle / positive regulation of cytokine production / positive regulation of interleukin-8 production / positive regulation of JNK cascade / regulation of protein phosphorylation / microglial cell activation / response to virus / response to molecule of bacterial origin / negative regulation of ERK1 and ERK2 cascade / positive regulation of non-canonical NF-kappaB signal transduction / male gonad development / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of type II interferon production / positive regulation of NF-kappaB transcription factor activity / regulation of inflammatory response / basolateral plasma membrane / cellular response to lipopolysaccharide / positive regulation of canonical NF-kappaB signal transduction / defense response to Gram-negative bacterium / defense response to virus / positive regulation of MAPK cascade / lysosome / endosome / immune response / apical plasma membrane / innate immune response / endoplasmic reticulum membrane / endoplasmic reticulum / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / membrane / plasma membrane Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 120 / Source method: isolated from a natural source / Formula: H2O
Sequence details
PROTEIN IS A CHIMERA COMPRISING RESIDUES 21-81 FROM UNP Q4G1L2, RESIDUES 480-753 FROM UNP Q9EQU3, ...PROTEIN IS A CHIMERA COMPRISING RESIDUES 21-81 FROM UNP Q4G1L2, RESIDUES 480-753 FROM UNP Q9EQU3, AND RESIDUES 126-200 FROM UNP Q4G1L2 FOLLOWED BY A C-TERMINAL EXPRESSION TAG.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 3.69 Å3/Da / Density % sol: 66.62 %
Crystal grow
Temperature: 295 K / Method: vapor diffusion, sitting drop / pH: 4.77 Details: 100 mM sodium citrate, 1.5 M ammonium sulfate, pH 4.77, VAPOR DIFFUSION, SITTING DROP, temperature 295K
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