Entry Database : PDB / ID : 4qd6 Structure visualization Downloads & linksTitle ITK kinase domain in complex with inhibitor compound ComponentsTyrosine-protein kinase ITK/TSK Details Keywords Transferase/transferase inhibitor / protein kinase / phosphotransfer catalyst / Transferase-transferase inhibitor complexFunction / homology Function and homology informationFunction Domain/homology Component
gamma-delta T cell activation / NK T cell differentiation / : / Generation of second messenger molecules / cellular defense response / T cell activation / FCERI mediated Ca+2 mobilization / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase ... gamma-delta T cell activation / NK T cell differentiation / : / Generation of second messenger molecules / cellular defense response / T cell activation / FCERI mediated Ca+2 mobilization / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cell-cell junction / T cell receptor signaling pathway / adaptive immune response / intracellular signal transduction / phosphorylation / signal transduction / ATP binding / nucleus / metal ion binding / plasma membrane / cytosol Similarity search - Function Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain ... Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.45 Å DetailsAuthors McEwan, P.A. / Barker, J.J. / Eigenbrot, C. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2014Title : Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).Authors: Trani, G. / Barker, J.J. / Bromidge, S.M. / Brookfield, F.A. / Burch, J.D. / Chen, Y. / Eigenbrot, C. / Heifetz, A. / Ismaili, M.H. / Johnson, A. / Krulle, T.M. / MacKinnon, C.H. / Maghames, ... Authors : Trani, G. / Barker, J.J. / Bromidge, S.M. / Brookfield, F.A. / Burch, J.D. / Chen, Y. / Eigenbrot, C. / Heifetz, A. / Ismaili, M.H. / Johnson, A. / Krulle, T.M. / MacKinnon, C.H. / Maghames, R. / McEwan, P.A. / Montalbetti, C.A. / Ortwine, D.F. / Perez-Fuertes, Y. / Vaidya, D.G. / Wang, X. / Zarrin, A.A. / Pei, Z. History Deposition May 13, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 14, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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