Entry Database : PDB / ID : 4q3h Structure visualization Downloads & linksTitle The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein ComponentsNa(+)/H(+) exchange regulatory cofactor NHE-RF1 Details Keywords IMMUNE SYSTEM / Scaffold protein / Dimerization / Neutrophil chemotaxisFunction / homology Function and homology informationFunction Domain/homology Component
interleukin-8-mediated signaling pathway / interleukin-8 receptor activity / mast cell granule / import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding ... interleukin-8-mediated signaling pathway / interleukin-8 receptor activity / mast cell granule / import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / cerebrospinal fluid circulation / interleukin-8 binding / microvillus assembly / positive regulation of monoatomic ion transmembrane transport / negative regulation of sodium ion transport / C-X-C chemokine receptor activity / bile acid secretion / maintenance of epithelial cell apical/basal polarity / plasma membrane organization / stereocilium tip / cilium organization / intracellular phosphate ion homeostasis / gland morphogenesis / myosin II binding / phospholipase C-activating dopamine receptor signaling pathway / growth factor receptor binding / establishment of Golgi localization / fibroblast migration / C-C chemokine receptor activity / type 3 metabotropic glutamate receptor binding / plasma membrane protein complex / C-C chemokine binding / establishment of epithelial cell apical/basal polarity / neutrophil activation / negative regulation of fibroblast migration / chloride channel regulator activity / negative regulation of platelet-derived growth factor receptor signaling pathway / auditory receptor cell stereocilium organization / Chemokine receptors bind chemokines / nuclear migration / regulation of protein kinase activity / dendritic cell chemotaxis / microvillus membrane / regulation of cell size / renal absorption / microvillus / transport across blood-brain barrier / negative regulation of mitotic cell cycle / phosphatase binding / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endomembrane system / cellular defense response / beta-2 adrenergic receptor binding / positive regulation of intrinsic apoptotic signaling pathway / protein-membrane adaptor activity / sperm midpiece / ruffle / neutrophil chemotaxis / secretory granule membrane / filopodium / cell periphery / protein localization to plasma membrane / PDZ domain binding / G protein-coupled receptor activity / morphogenesis of an epithelium / calcium-mediated signaling / brush border membrane / sensory perception of sound / negative regulation of canonical Wnt signaling pathway / receptor internalization / negative regulation of ERK1 and ERK2 cascade / mitotic spindle / beta-catenin binding / Wnt signaling pathway / adenylate cyclase-activating dopamine receptor signaling pathway / chemotaxis / : / microtubule cytoskeleton / actin cytoskeleton / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of cell shape / G alpha (i) signalling events / positive regulation of cytosolic calcium ion concentration / actin cytoskeleton organization / protein-containing complex assembly / vesicle / transmembrane transporter binding / cell surface receptor signaling pathway / inflammatory response / immune response / apical plasma membrane / negative regulation of cell population proliferation / external side of plasma membrane / signaling receptor binding / positive regulation of cell population proliferation / Neutrophil degranulation / protein-containing complex binding Similarity search - Function CXC chemokine receptor 2 / CXC chemokine receptor 1/2 / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. ... CXC chemokine receptor 2 / CXC chemokine receptor 1/2 / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.443 Å DetailsAuthors Holcomb, J. / Jiang, Y. / Trescott, L. / Lu, G. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. CitationJournal : Biochem.Biophys.Res.Commun. / Year : 2014Title : Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization.Authors : Holcomb, J. / Jiang, Y. / Guan, X. / Trescott, L. / Lu, G. / Hou, Y. / Wang, S. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. History Deposition Apr 11, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 21, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Jun 18, 2014 Group : Database referencesRevision 1.2 Aug 16, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Feb 28, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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