Entry Database : PDB / ID : 4q3h Structure visualization Downloads & linksTitle The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein ComponentsNa(+)/H(+) exchange regulatory cofactor NHE-RF1 Details Keywords IMMUNE SYSTEM / Scaffold protein / Dimerization / Neutrophil chemotaxisFunction / homology Function and homology informationFunction Domain/homology Component
interleukin-8-mediated signaling pathway / metanephric tubule morphogenesis / negative regulation of neutrophil apoptotic process / interleukin-8 receptor activity / mast cell granule / dopamine receptor binding / import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport ... interleukin-8-mediated signaling pathway / metanephric tubule morphogenesis / negative regulation of neutrophil apoptotic process / interleukin-8 receptor activity / mast cell granule / dopamine receptor binding / import across plasma membrane / channel activator activity / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / renal phosphate ion absorption / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / interleukin-8 binding / cerebrospinal fluid circulation / negative regulation of sodium ion transport / microvillus assembly / positive regulation of monoatomic ion transmembrane transport / C-X-C chemokine receptor activity / acute inflammatory response to antigenic stimulus / bile acid secretion / maintenance of epithelial cell apical/basal polarity / intracellular phosphate ion homeostasis / cilium organization / plasma membrane organization / stereocilium tip / gland morphogenesis / myosin II binding / phospholipase C-activating dopamine receptor signaling pathway / growth factor receptor binding / C-C chemokine receptor activity / neutrophil activation / C-C chemokine binding / establishment of Golgi localization / fibroblast migration / type 3 metabotropic glutamate receptor binding / plasma membrane protein complex / positive regulation of vascular permeability / establishment of epithelial cell apical/basal polarity / negative regulation of fibroblast migration / chloride channel regulator activity / negative regulation of platelet-derived growth factor receptor signaling pathway / positive regulation of neutrophil chemotaxis / auditory receptor cell stereocilium organization / Chemokine receptors bind chemokines / nuclear migration / regulation of protein kinase activity / dendritic cell chemotaxis / beta-2 adrenergic receptor binding / microvillus membrane / regulation of cell size / midbrain development / renal absorption / positive regulation of cardiac muscle cell apoptotic process / microvillus / transport across blood-brain barrier / negative regulation of mitotic cell cycle / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endomembrane system / phosphatase binding / cellular defense response / protein-membrane adaptor activity / positive regulation of intrinsic apoptotic signaling pathway / sperm midpiece / ruffle / neutrophil chemotaxis / secretory granule membrane / filopodium / PDZ domain binding / cell periphery / G protein-coupled receptor activity / calcium-mediated signaling / protein localization to plasma membrane / morphogenesis of an epithelium / brush border membrane / sensory perception of sound / negative regulation of canonical Wnt signaling pathway / negative regulation of ERK1 and ERK2 cascade / receptor internalization / mitotic spindle / beta-catenin binding / Wnt signaling pathway / adenylate cyclase-activating dopamine receptor signaling pathway / positive regulation of angiogenesis / : / microtubule cytoskeleton / chemotaxis / actin cytoskeleton / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / regulation of cell shape / G alpha (i) signalling events / actin cytoskeleton organization / protein-containing complex assembly / vesicle / transmembrane transporter binding / cell surface receptor signaling pathway / immune response Similarity search - Function CXC chemokine receptor 2 / CXC chemokine receptor 1/2 / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. ... CXC chemokine receptor 2 / CXC chemokine receptor 1/2 / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.443 Å DetailsAuthors Holcomb, J. / Jiang, Y. / Trescott, L. / Lu, G. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. CitationJournal : Biochem.Biophys.Res.Commun. / Year : 2014Title : Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization.Authors : Holcomb, J. / Jiang, Y. / Guan, X. / Trescott, L. / Lu, G. / Hou, Y. / Wang, S. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. History Deposition Apr 11, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 21, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Jun 18, 2014 Group : Database referencesRevision 1.2 Aug 16, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Feb 28, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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