登録情報 | データベース: PDB / ID: 4p0c |
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タイトル | Crystal Structure of NHERF2 PDZ1 Domain in Complex with LPA2 |
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要素 | Na(+)/H(+) exchange regulatory cofactor NHE-RF2/Lysophosphatidic acid receptor 2 chimeric protein |
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キーワード | PROTEIN BINDING / PDZ / protein-protein interaction |
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機能・相同性 | 機能・相同性情報
lysophosphatidic acid receptor activity / type 2 metabotropic glutamate receptor binding / Lysosphingolipid and LPA receptors / type 3 metabotropic glutamate receptor binding / regulation of metabolic process / plasma membrane => GO:0005886 / : / phosphatase binding / endomembrane system / protein-membrane adaptor activity ...lysophosphatidic acid receptor activity / type 2 metabotropic glutamate receptor binding / Lysosphingolipid and LPA receptors / type 3 metabotropic glutamate receptor binding / regulation of metabolic process / plasma membrane => GO:0005886 / : / phosphatase binding / endomembrane system / protein-membrane adaptor activity / protein localization to plasma membrane / G protein-coupled receptor activity / adenylate cyclase-activating G protein-coupled receptor signaling pathway / beta-catenin binding / positive regulation of cytosolic calcium ion concentration / G alpha (i) signalling events / G alpha (q) signalling events / protein-containing complex assembly / cadherin binding / G protein-coupled receptor signaling pathway / apical plasma membrane / focal adhesion / signaling receptor binding / lipid binding / cell surface / extracellular exosome / identical protein binding / nucleus / plasma membrane / cytoplasm類似検索 - 分子機能 Lysophosphatidic acid receptor EDG-4 / Lysophosphatidic acid receptor / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / Serpentine type 7TM GPCR chemoreceptor Srsx / PDZ domain / PDZ domain profile. ...Lysophosphatidic acid receptor EDG-4 / Lysophosphatidic acid receptor / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / PDZ domain / Pdz3 Domain / Serpentine type 7TM GPCR chemoreceptor Srsx / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Roll / Mainly Beta類似検索 - ドメイン・相同性 THIOCYANATE ION / Na(+)/H(+) exchange regulatory cofactor NHE-RF2 / Lysophosphatidic acid receptor 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.339 Å |
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データ登録者 | Holcomb, J. / Jiang, Y. / Lu, G. / Trescott, L. / Brunzelle, J. / Sirinupong, N. / Li, C. / Naren, A. / Yang, Z. |
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引用 | ジャーナル: Biochem.Biophys.Res.Commun. / 年: 2014 タイトル: Structural insights into PDZ-mediated interaction of NHERF2 and LPA2, a cellular event implicated in CFTR channel regulation. 著者: Holcomb, J. / Jiang, Y. / Lu, G. / Trescott, L. / Brunzelle, J. / Sirinupong, N. / Li, C. / Naren, A.P. / Yang, Z. |
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履歴 | 登録 | 2014年2月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年5月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年2月4日 | Group: Derived calculations |
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改定 1.2 | 2023年12月27日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Derived calculations / Other / Refinement description / Source and taxonomy カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / diffrn_radiation_wavelength / entity_src_gen / pdbx_database_status / pdbx_prerelease_seq / pdbx_struct_assembly / pdbx_struct_oper_list / pdbx_validate_close_contact / pdbx_validate_symm_contact / refine_hist Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation / _pdbx_validate_symm_contact.auth_atom_id_1 / _pdbx_validate_symm_contact.auth_atom_id_2 / _pdbx_validate_symm_contact.dist |
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改定 1.3 | 2024年3月27日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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