Entry Database : PDB / ID : 4ova Structure visualization Downloads & linksTitle Structure of the two tandem Tudor domains and a new identified KH0 domain from human Fragile X Mental Retardation Protein ComponentsFragile X mental retardation protein 1 Details Keywords RNA BINDING PROTEIN / KH DOMAIN / FRAGILE X MENTAL RETARDATION PROTEIN / FMRP / tandem Tudor domains / EUKARYOTIC KH DOMAINS / KH0 domain / protein interactionFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of intracellular transport of viral material / regulation of translation at presynapse, modulating synaptic transmission / modulation by host of viral RNA genome replication / regulation of neuronal action potential / growth cone filopodium / poly(G) binding / positive regulation of miRNA-mediated gene silencing / negative regulation of miRNA-mediated gene silencing / negative regulation of long-term synaptic depression / neuronal ribonucleoprotein granule ... positive regulation of intracellular transport of viral material / regulation of translation at presynapse, modulating synaptic transmission / modulation by host of viral RNA genome replication / regulation of neuronal action potential / growth cone filopodium / poly(G) binding / positive regulation of miRNA-mediated gene silencing / negative regulation of miRNA-mediated gene silencing / negative regulation of long-term synaptic depression / neuronal ribonucleoprotein granule / animal organ development / negative regulation of voltage-gated calcium channel activity / dendritic filopodium / RNA strand annealing activity / chromocenter / regulation of dendritic spine development / positive regulation of long-term neuronal synaptic plasticity / filopodium tip / regulation of neurotransmitter secretion / regulation of filopodium assembly / negative regulation of synaptic vesicle exocytosis / non-membrane-bounded organelle assembly / regulatory ncRNA-mediated gene silencing / poly(A) binding / positive regulation of proteasomal protein catabolic process / N6-methyladenosine-containing RNA reader activity / siRNA binding / poly(U) RNA binding / glutamate receptor signaling pathway / sequence-specific mRNA binding / miRNA binding / positive regulation of filopodium assembly / intracellular non-membrane-bounded organelle / dynein complex binding / positive regulation of dendritic spine development / dendritic spine neck / regulation of alternative mRNA splicing, via spliceosome / glial cell projection / positive regulation of receptor internalization / chromosome, centromeric region / mRNA transport / negative regulation of cytoplasmic translation / translation regulator activity / mRNA export from nucleus / signaling adaptor activity / Cajal body / stress granule assembly / axon terminus / translation repressor activity / negative regulation of translational initiation / translation initiation factor binding / regulation of mRNA stability / methylated histone binding / RNA splicing / molecular condensate scaffold activity / mRNA 3'-UTR binding / cell projection / positive regulation of translation / mRNA processing / cellular response to virus / mRNA 5'-UTR binding / cytoplasmic ribonucleoprotein granule / cytoplasmic stress granule / RNA stem-loop binding / presynapse / ribosome binding / presynaptic membrane / chromosome / nervous system development / growth cone / G-quadruplex RNA binding / postsynapse / microtubule binding / postsynaptic membrane / perikaryon / transmembrane transporter binding / dendritic spine / postsynaptic density / negative regulation of translation / ribonucleoprotein complex / neuron projection / positive regulation of protein phosphorylation / protein heterodimerization activity / axon / DNA repair / mRNA binding / synapse / chromatin binding / dendrite / nucleolus / perinuclear region of cytoplasm / protein homodimerization activity / RNA binding / nucleoplasm / identical protein binding / membrane / nucleus / cytoplasm / cytosol Similarity search - Function Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / : / : / : / : / Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / Fragile X messenger ribonucleoprotein 1, C-terminal core / Fragile X messenger ribonucleoprotein 1 / Synaptic functional regulator FMRP, KH0 domain / FMR1, tudor domain ... Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / : / : / : / : / Fragile X messenger ribonucleoprotein 1, C-terminal region 2 / Fragile X messenger ribonucleoprotein 1, C-terminal core / Fragile X messenger ribonucleoprotein 1 / Synaptic functional regulator FMRP, KH0 domain / FMR1, tudor domain / Fragile X-related 1 protein core C terminal / FMRP KH0 domain / Fragile X messenger ribonucleoprotein 1, Tudor domain / Agenet-like domain profile. / Agenet-like domain / Agenet domain / KH domain / K Homology domain, type 1 / Type-1 KH domain profile. / SH3 type barrels. - #140 / K Homology domain, type 1 superfamily / K Homology domain / K homology RNA-binding domain / SH3 type barrels. / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Chen, Z.H. / Chen, Z.Z. CitationJournal : Nat Commun / Year : 2015Title : The amino-terminal structure of human fragile X mental retardation protein obtained using precipitant-immobilized imprinted polymersAuthors : Hu, Y. / Chen, Z.H. / Fu, Y. / He, Q. / Jiang, L. / Zheng, J. / Gao, Y. / Mei, P. / Chen, Z.Z. / Ren, X. History Deposition Feb 21, 2014 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Feb 25, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Oct 21, 2015 Group : Database referencesRevision 1.2 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less