Entry Database : PDB / ID : 4ons Structure visualization Downloads & linksTitle Structural and thermodynamic characterization of cadherin-beta-catenin-alpha-catenin complex formation ComponentsCatenin alpha-2 Catenin beta-1 DetailsKeywords CELL ADHESION / four helix bundlesFunction / homology Function and homology informationFunction Domain/homology Component
radial glia guided migration of Purkinje cell / lung cell differentiation / epicardium-derived cardiac vascular smooth muscle cell differentiation / mesenchyme morphogenesis / RUNX3 regulates WNT signaling / Regulation of CDH11 function / cardiac vascular smooth muscle cell differentiation / extrinsic component of postsynaptic membrane / Beta-catenin phosphorylation cascade / regulation of synapse structural plasticity ... radial glia guided migration of Purkinje cell / lung cell differentiation / epicardium-derived cardiac vascular smooth muscle cell differentiation / mesenchyme morphogenesis / RUNX3 regulates WNT signaling / Regulation of CDH11 function / cardiac vascular smooth muscle cell differentiation / extrinsic component of postsynaptic membrane / Beta-catenin phosphorylation cascade / regulation of synapse structural plasticity / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Apoptotic cleavage of cell adhesion proteins / hair cycle process / positive regulation of epithelial cell differentiation / TCF dependent signaling in response to WNT / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / trachea morphogenesis / mesenchyme development / endoderm formation / Formation of the beta-catenin:TCF transactivating complex / VEGFR2 mediated vascular permeability / positive regulation of heparan sulfate proteoglycan biosynthetic process / lung induction / positive regulation of branching involved in lung morphogenesis / cranial ganglion development / renal vesicle formation / renal inner medulla development / renal outer medulla development / nephron tubule formation / mesenchymal stem cell differentiation / beta-catenin-ICAT complex / metanephros morphogenesis / genitalia morphogenesis / embryonic skeletal limb joint morphogenesis / neural plate development / Deactivation of the beta-catenin transactivating complex / glial cell fate determination / regulation of secondary heart field cardioblast proliferation / astrocyte-dopaminergic neuron signaling / negative regulation of mitotic cell cycle, embryonic / canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation / oviduct development / beta-catenin-TCF7L2 complex / regulation of nephron tubule epithelial cell differentiation / negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / regulation of timing of anagen / extrinsic component of presynaptic membrane / Ca2+ pathway / central nervous system vasculogenesis / animal organ development / regulation of epithelial cell differentiation / Schwann cell proliferation / regulation of centriole-centriole cohesion / glandular epithelial cell differentiation / Degradation of beta-catenin by the destruction complex / modification of postsynaptic actin cytoskeleton / RHO GTPases activate IQGAPs / regulation of centromeric sister chromatid cohesion / Adherens junctions interactions / embryonic axis specification / endodermal cell fate commitment / ventricular compact myocardium morphogenesis / morphogenesis of embryonic epithelium / Scrib-APC-beta-catenin complex / beta-catenin-TCF complex / lens morphogenesis in camera-type eye / positive regulation of fibroblast growth factor receptor signaling pathway / dorsal root ganglion development / negative regulation of Arp2/3 complex-mediated actin nucleation / synaptic vesicle clustering / acinar cell differentiation / dorsal/ventral axis specification / proximal/distal pattern formation / neuron fate determination / regulation of neuron migration / layer formation in cerebral cortex / positive regulation of myoblast proliferation / positive regulation of endothelial cell differentiation / establishment of blood-retinal barrier / sympathetic ganglion development / fungiform papilla formation / lung epithelial cell differentiation / delta-catenin binding / embryonic foregut morphogenesis / hindbrain development / regulation of calcium ion import / positive regulation of skeletal muscle tissue development / positive regulation of determination of dorsal identity / ectoderm development / positive regulation of odontoblast differentiation / regulation of osteoclast differentiation / cranial skeletal system development / regulation of protein localization to cell surface / cellular response to indole-3-methanol / mesenchymal cell proliferation involved in lung development / endothelial tube morphogenesis / presynaptic active zone cytoplasmic component / smooth muscle cell differentiation / cell projection membrane / histone methyltransferase binding Similarity search - Function Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2780 / Alpha-catenin / Alpha-catenin/vinculin-like / Beta-catenin / Vinculin, conserved site / Vinculin family talin-binding region signature. / Vinculin/alpha-catenin / Vinculin family / Alpha-catenin/vinculin-like superfamily / Armadillo/plakoglobin ARM repeat profile. ... Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #2780 / Alpha-catenin / Alpha-catenin/vinculin-like / Beta-catenin / Vinculin, conserved site / Vinculin family talin-binding region signature. / Vinculin/alpha-catenin / Vinculin family / Alpha-catenin/vinculin-like superfamily / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Four Helix Bundle (Hemerythrin (Met), subunit A) / Helix non-globular / Special / Armadillo-like helical / Armadillo-type fold / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.8 Å DetailsAuthors Pokutta, S. / Choi, H.-J. / Ahlsen, G. / Hansen, S.D. / Weis, W.I. CitationJournal : J.Biol.Chem. / Year : 2014Title : Structural and Thermodynamic Characterization of Cadherin beta-Catenin alpha-Catenin Complex Formation.Authors : Pokutta, S. / Choi, H.J. / Ahlsen, G. / Hansen, S.D. / Weis, W.I. History Deposition Jan 29, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 9, 2014 Provider : repository / Type : Initial releaseRevision 1.1 May 7, 2014 Group : Database referencesRevision 1.2 May 28, 2014 Group : Database referencesRevision 1.3 Feb 28, 2024 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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