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基本情報
登録情報 | データベース: PDB / ID: 4om7 | ||||||
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タイトル | Crystal structure of TIR domain of TLR6 | ||||||
![]() | Toll-like receptor 6 | ||||||
![]() | SIGNALING PROTEIN / TIR fold / Protein interaction | ||||||
機能・相同性 | ![]() toll-like receptor 6 signaling pathway / regulation of cytokine production => GO:0001817 / interleukin-1 beta production / : / toll-like receptor TLR6:TLR2 signaling pathway / Toll Like Receptor TLR6:TLR2 Cascade / Toll-like receptor 2-Toll-like receptor 6 protein complex / detection of diacyl bacterial lipopeptide / cellular response to diacyl bacterial lipopeptide / cellular response to bacterial lipopeptide ...toll-like receptor 6 signaling pathway / regulation of cytokine production => GO:0001817 / interleukin-1 beta production / : / toll-like receptor TLR6:TLR2 signaling pathway / Toll Like Receptor TLR6:TLR2 Cascade / Toll-like receptor 2-Toll-like receptor 6 protein complex / detection of diacyl bacterial lipopeptide / cellular response to diacyl bacterial lipopeptide / cellular response to bacterial lipopeptide / negative regulation of toll-like receptor 2 signaling pathway / Toll-like receptor 2 binding / NADP+ nucleosidase activity / cellular response to oxidised low-density lipoprotein particle stimulus / negative regulation of interleukin-8 production / cell activation / Regulation of TLR by endogenous ligand / lipopeptide binding / TRIF-dependent toll-like receptor signaling pathway / ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase / activation of NF-kappaB-inducing kinase activity / NAD+ nucleotidase, cyclic ADP-ribose generating / positive regulation of cytokine production involved in inflammatory response / positive regulation of macrophage activation / MyD88 deficiency (TLR2/4) / MyD88-dependent toll-like receptor signaling pathway / positive regulation of reactive oxygen species biosynthetic process / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / positive regulation of NLRP3 inflammasome complex assembly / toll-like receptor signaling pathway / nitric oxide metabolic process / plasma membrane => GO:0005886 / positive regulation of JUN kinase activity / microglial cell activation / cellular response to amyloid-beta / phagocytic vesicle membrane / transmembrane signaling receptor activity / positive regulation of interleukin-6 production / positive regulation of nitric oxide biosynthetic process / signaling receptor activity / positive regulation of NF-kappaB transcription factor activity / amyloid-beta binding / ER-Phagosome pathway / positive regulation of canonical NF-kappaB signal transduction / receptor complex / defense response to bacterium / inflammatory response / immune response / membrane raft / protein heterodimerization activity / innate immune response / signaling receptor binding / positive regulation of gene expression / Golgi apparatus / signal transduction / identical protein binding / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | ![]() ![]() ![]() | ||||||
![]() | Park, H.H. / Jang, T.H. | ||||||
![]() | ![]() タイトル: Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR-TIR Interaction for Toll-Like Receptor Signaling Pathway. 著者: Jang, T.H. / Park, H.H. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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PDBx/mmCIF形式 | ![]() | 68.5 KB | 表示 | ![]() |
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PDB形式 | ![]() | 54.4 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 442.7 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 446.5 KB | 表示 | |
XML形式データ | ![]() | 12.3 KB | 表示 | |
CIF形式データ | ![]() | 15.9 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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単位格子 |
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Components on special symmetry positions |
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要素
#1: タンパク質 | 分子量: 21210.295 Da / 分子数: 2 / 断片: UNP residues 640-796 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() #2: 水 | ChemComp-HOH / | |
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-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.2 Å3/Da / 溶媒含有率: 44.18 % |
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結晶化 | 温度: 298 K / 手法: 蒸気拡散法, ハンギングドロップ法 / pH: 8.6 詳細: 0.2M lithium sulfate monohydrate, 0.1M Tris pH 8.6, 25%(w/v) polyethylene glycol 3350 and 4%(v/v) formamide, VAPOR DIFFUSION, HANGING DROP, temperature 298K |
-データ収集
回折 | 平均測定温度: 110 K |
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放射光源 | 由来: ![]() ![]() |
検出器 | タイプ: ADSC QUANTUM 315r / 検出器: CCD / 日付: 2013年7月8日 |
放射 | モノクロメーター: GRAPHITE / プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray |
放射波長 | 波長: 1 Å / 相対比: 1 |
反射 | 解像度: 2.2→35 Å / Num. obs: 18245 / % possible obs: 14 % / Observed criterion σ(F): 2.4 / Observed criterion σ(I): 2.4 |
反射 シェル | 解像度: 2.2→2.4 Å / % possible all: 92 |
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解析
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精密化 | 構造決定の手法: ![]()
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溶媒の処理 | 減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 2.204→31.822 Å
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拘束条件 |
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LS精密化 シェル |
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