登録情報 | データベース: PDB / ID: 4ny3 |
---|
タイトル | Human PTPA in complex with peptide |
---|
要素 | - Serine/threonine-protein phosphatase 2A activator
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
|
---|
キーワード | HYDROLASE ACTIVATOR / PTPA / PPP2R4 / REGULATORY SUBUNIT B' (PR 53) / PROTEIN PHOSPHATASE 2A (PP2A) |
---|
機能・相同性 | 機能・相同性情報
protein tyrosine phosphatase activator activity / Integration of energy metabolism / regulation of phosphoprotein phosphatase activity / PP2A-mediated dephosphorylation of key metabolic factors / regulation of microtubule binding / MASTL Facilitates Mitotic Progression / negative regulation of protein dephosphorylation / protein phosphatase type 2A complex / peptidyl-serine dephosphorylation / peptidyl-threonine dephosphorylation ...protein tyrosine phosphatase activator activity / Integration of energy metabolism / regulation of phosphoprotein phosphatase activity / PP2A-mediated dephosphorylation of key metabolic factors / regulation of microtubule binding / MASTL Facilitates Mitotic Progression / negative regulation of protein dephosphorylation / protein phosphatase type 2A complex / peptidyl-serine dephosphorylation / peptidyl-threonine dephosphorylation / positive regulation of microtubule binding / Regulation of glycolysis by fructose 2,6-bisphosphate metabolism / Inhibition of replication initiation of damaged DNA by RB1/E2F1 / protein phosphatase regulator activity / GABA receptor binding / APC truncation mutants have impaired AXIN binding / AXIN missense mutants destabilize the destruction complex / Truncations of AMER1 destabilize the destruction complex / Initiation of Nuclear Envelope (NE) Reformation / ERKs are inactivated / Beta-catenin phosphorylation cascade / Signaling by GSK3beta mutants / CTNNB1 S33 mutants aren't phosphorylated / CTNNB1 S37 mutants aren't phosphorylated / CTNNB1 S45 mutants aren't phosphorylated / CTNNB1 T41 mutants aren't phosphorylated / negative regulation of epithelial to mesenchymal transition / regulation of growth / Disassembly of the destruction complex and recruitment of AXIN to the membrane / negative regulation of glycolytic process through fructose-6-phosphate / positive regulation of NLRP3 inflammasome complex assembly / myosin phosphatase activity / negative regulation of phosphoprotein phosphatase activity / CTLA4 inhibitory signaling / protein serine/threonine phosphatase activity / Platelet sensitization by LDL / ATPase complex / protein-serine/threonine phosphatase / regulation of cell differentiation / ERK/MAPK targets / T cell homeostasis / regulation of G1/S transition of mitotic cell cycle / mesoderm development / positive regulation of phosphoprotein phosphatase activity / phosphoprotein phosphatase activity / chromosome, centromeric region / DARPP-32 events / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Cyclin A/B1/B2 associated events during G2/M transition / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / positive regulation of protein dephosphorylation / Resolution of Sister Chromatid Cohesion / calcium channel complex / protein dephosphorylation / mitotic spindle organization / meiotic cell cycle / protein phosphatase 2A binding / peptidylprolyl isomerase / protein tyrosine phosphatase activity / peptidyl-prolyl cis-trans isomerase activity / RHO GTPases Activate Formins / response to lead ion / RAF activation / Spry regulation of FGF signaling / regulation of protein phosphorylation / Degradation of beta-catenin by the destruction complex / tau protein binding / PKR-mediated signaling / positive regulation of protein serine/threonine kinase activity / spindle pole / Negative regulation of MAPK pathway / Separation of Sister Chromatids / Cyclin D associated events in G1 / microtubule cytoskeleton / Regulation of TP53 Degradation / mitotic cell cycle / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / intracellular signal transduction / positive regulation of apoptotic process / membrane raft / protein heterodimerization activity / signaling receptor binding / synapse / protein homodimerization activity / mitochondrion / extracellular exosome / nucleoplasm / ATP binding / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Phosphotyrosyl phosphate activator, C-terminal lid domain / Phosphotyrosyl phosphatase activator, PTPA / PTPA superfamily / Phosphotyrosyl phosphatase activator, C-terminal lid domain / Phosphotyrosyl phosphate activator (PTPA) protein / : / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Calcineurin-like phosphoesterase domain, ApaH type ...Phosphotyrosyl phosphate activator, C-terminal lid domain / Phosphotyrosyl phosphatase activator, PTPA / PTPA superfamily / Phosphotyrosyl phosphatase activator, C-terminal lid domain / Phosphotyrosyl phosphate activator (PTPA) protein / : / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / Four Helix Bundle (Hemerythrin (Met), subunit A) / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / Serine/threonine-protein phosphatase 2A activator類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.797 Å |
---|
データ登録者 | Loew, C. / Quistgaard, E.M. / Nordlund, P. |
---|
引用 | ジャーナル: Biol.Chem. / 年: 2014 タイトル: Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A. 著者: Low, C. / Quistgaard, E.M. / Kovermann, M. / Anandapadamanaban, M. / Balbach, J. / Nordlund, P. |
---|
履歴 | 登録 | 2013年12月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2014年7月23日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|